Same-chemical comparison of nonanimal eye irritation test methods: Bovine corneal opacity and permeability, EpiOcular™, isolated chicken eye, ocular Irritection®, OptiSafe™, and short time exposure.
Same-chemical comparison of nonanimal eye irritation test methods: Bovine corneal opacity and permeability, EpiOcular™, isolated chicken eye, ocular Irritection®, OptiSafe™, and short time exposure.
复制标题
DOI：
10.1016/j.tiv.2020.105070
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Jester JV
中科院分区：
文献类型：
--
作者：
Lebrun S;Nguyen L;Chavez S;Chan R;Le D;Nguyen M;Jester JV
确定不良眼部影响的化学品测试和分类是常规进行的，以确保材料得到适当的分类、标签，并符合法规和安全指南。我们使用公开可用的验证研究结果进行了相同的化学分析，并比较了相同化学物质的测试之间的性能。为了使化学选择标准化，我们匹配了通过成对测试测试的化学物质，以便每一组匹配的化学物质都比较了完全相同的化学物质的性能。相同的化学准确度比较表明，化学选择效应导致所有测试方法的重叠假阳性(FP)率和准确度范围很大。此外，分析表明，具有特定测试组合的分级测试策略可以降低某些组合的FP率。然而，FP率的降低通常伴随着假阴性率的增加，导致准确性方面的优势微乎其微。此外，在用第二次测试重新测试阳性后FP率的实际改善不如理论改进，因为一些化学品和官能团似乎被所有测试方法广泛地错误分类，这在一定程度上降低了使用分级测试策略的优势。
The testing and classification of chemicals to determine adverse ocular effects are routinely conducted to ensure that materials are appropriately classified, labeled, and meet regulatory and safety guidelines. We have performed a same-chemical analysis using publicly available validation study results and compared the performance between tests for the same chemicals. To normalize for chemical selection, we matched chemicals tested by pairs of tests so that each matched set compared performance for the exact same chemicals. Same-chemical accuracy comparisons demonstrate a chemical selection effect that results in a wide range of overlapping false-positive (FP) rates and accuracies for all test methods. In addition, the analysis suggests that a tiered-testing strategy with specific combinations of tests can reduce the FP rate for some combinations. However, reductions in the FP rates were typically accompanied by an increase in the false-negative rates, resulting in minimal advantage in terms of accuracy. In addition, actual improvements in the FP rate after retesting positives with a second test are not as good as the theoretical improvements because some chemicals and functional groups appear to be broadly misclassified by all test methods, which, to the extent the tests make the same-chemical misclassifications, reduces the advantage of using tiered-testing strategies.
登录
查看更多内容
影响因子：
3.2
作者：
GAUTHERON, P;GIROUX, J;SPIELMANN, H
通讯作者：
SPIELMANN, H
影响因子：
3.2
作者：
Adriaens, E.;Verstraelen, S.;Van Rompay, A. R.
通讯作者：
Van Rompay, A. R.
影响因子：
3.2
作者：
Jung, Kyoung-Mi;Lee, Su-Hyon;Lim, Kyung-Min
通讯作者：
Lim, Kyung-Min
影响因子：
2.7
作者：
Hayashi, Kazuhiko;Abo, Takayuki;Sakaguchi, Hitoshi
通讯作者：
Sakaguchi, Hitoshi
影响因子：
3.2
作者：
Kandarova, H.;Letasiova, S.;Van Rompay, An R.
通讯作者：
Van Rompay, An R.