Development of a murine model of chronic rhinosinusitis
Development of a murine model of chronic rhinosinusitis
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DOI：
10.1016/j.otohns.2005.11.048
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发表时间：
2006-05-01
影响因子：
3.4
通讯作者：
Bolger, WE
中科院分区：
文献类型：
--
作者：
Lindsay, R;Slaughter, T;Bolger, WE
目的：本研究的目的是建立慢性嗜酸性鼻窦炎的小鼠模型。研究设计：小鼠腹腔注射烟曲霉（Af）提取物致敏。随后，动物每周接受3次Af提取物的鼻攻击，持续12周。鼻腔鼻窦复合体进行了组织学研究，研究耳鼻喉科医生和病理学家的特点炎症responsibility.Setting：动物护理设施在学术institution.Results：慢性嗜酸性粒细胞炎症反应诱发的所有研究动物。对炎症、分泌细胞增生、肥大细胞和嗜酸性粒细胞进行统计分析。差异有非常显著性意义（P
Objective: The aim of this study was to develop a mouse model of chronic eosinophilic rhinosinusitis.Study Design: Mice were sensitized to Aspergillis fumigatus (Af) extract by intraperitoneal injection. The animals subsequently received nasal challenges with Af extract 3 times per week for 12 weeks. Sinonasal complexes were studied histologically by the study otolaryngologists and pathologists to characterize the inflammatory response.Setting: Animal care facility at an academic institution.Results: A chronic eosinophilic inflammatory response was evoked in all study animals. Statistical analysis was performed for inflammation, secretory cell hyperplasia, mast cells, and eosinophils. There were very significant differences (P