Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers.
Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers.
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与结直肠癌和腺瘤有关的与饮酒相关的代谢物：使用血清生物标志物进行两项病例对照研究。
DOI：
10.1371/journal.pone.0150962
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Abnet CC
中科院分区：
文献类型：
--
作者：
Troche JR;Mayne ST;Freedman ND;Shebl FM;Guertin KA;Cross AJ;Abnet CC
酒精是一种已知的致癌物质，可能与结直肠癌有关。然而，大多数流行病学研究使用自我报告的数据来评估酒精饮料的消费，导致潜在的接触错误分类。酒精消费的生物标记物可能提供一种替代的、互补的方法，减少错误分类，并将酒精代谢的个体差异纳入其中。因此，我们利用两项研究的血清代谢组学数据，评估了先前发现的与饮酒相关的代谢物与结直肠癌和腺瘤的关系。关于结直肠癌的数据来自于前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中对502名美国成年人(252例，250名对照)的嵌套病例对照研究。有关结直肠腺瘤的数据来自海军结肠腺瘤研究中对197名美国成年人(120例，77名对照)的病例对照研究。非条件多变量Logistic回归模型适合于计算先前分析中确定的8种与酒精消费相关的代谢物的优势比(OR)和95%可信区间(CI)：乙基葡萄糖醛酸乙酯；4-雄烯-3β，17-β-二醇二硫酸盐1；5-α-雄烷-3-β，17-β-二醇二硫酸盐；16-羟基丙二酸酯；胆红素(E，Z或Z，E)；环状(-亮氨酸-Pro)；亚油酸二高酯(20：2n6)和棕榈油酸酯(16：1n7)。我们没有发现这些与饮酒相关的代谢物与任何一个终点之间存在明显的关联。然而，我们确实观察到环状(-亮氨酸-Pro)与结直肠腺瘤呈负相关，仅在最高代谢物分位数(OR4vs.1分位数=0.3，95%可信区间：0.12-0.78；P-趋势=0.047)，而与结直肠癌无关。总而言之，与饮酒相关的代谢物与结直肠癌或腺瘤没有不良关联。
Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementary approach that reduces misclassification and incorporates individual differences in alcohol metabolism. Therefore, we evaluated the relationship between previously identified alcohol consumption-related metabolites and colorectal cancer and adenoma using serum metabolomics data from two studies. Data on colorectal cancer were obtained from a nested case-control study of 502 US adults (252 cases, 250 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Data on colorectal adenoma were obtained from a case-control study of 197 US adults (120 cases, 77 controls) from the Navy Colon Adenoma Study. Unconditional multivariable logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for eight alcohol consumption-related metabolites identified in a previous analysis: ethyl glucuronide; 4-androstene-3beta,17beta-diol disulfate 1; 5-alpha-androstan-3beta,17beta-diol disulfate; 16-hydroxypalmitate; bilirubin (E,Z or Z,E); cyclo (-leu-pro); dihomo-linoleate (20:2n6); and palmitoleate (16:1n7). We found no clear association between these alcohol consumption-related metabolites and either endpoint. However, we did observe an inverse association between cyclo (-leu-pro) and colorectal adenoma that was only observed in the highest metabolite quantile (OR 4th vs. 1st Quantile = 0.30, 95% CI: 0.12–0.78; P-trend = 0.047), but no association for colorectal cancer. In conclusion, there were no adverse associations between alcohol consumption-related metabolites and colorectal cancer or adenoma.