Improved wound healing response in surgical patients receiving intravenous nutrition
Improved wound healing response in surgical patients receiving intravenous nutrition
复制标题
接受静脉营养的手术患者伤口愈合反应得到改善
DOI：
10.1002/bjs.1800740432
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发表时间：
1987
影响因子：
9.6
通讯作者：
G. Hill
中科院分区：
文献类型：
--
作者：
D. Haydock;G. Hill
90例手术患者的伤口愈合反应是通过测量7天内羟基吡咯碱在手臂皮下放置的薄壁GORE - TEX细管中的积累来评估的。47例静脉营养患者的伤口愈合反应（0.34±0.23 μg羟脯氨酸/cm管）低于36例正常营养患者（0.49±0.30 μg/cm; P < 0.01）。而静脉给药后测得的血凝素含量更高（0.88±0.62 μg/cm; P < 0.005）。在29例患者中，两项连续的伤口愈合研究在14天的静脉营养期间进行。静脉营养第一周羟脯氨酸的平均积累量为0.36±0.24 μg/cm，第二周显著增加至0.78±0.67 μg/cm；P < 0·005。术前营养一段时间创面愈合反应优于术后营养一段时间创面愈合反应（P < 0.02）。这些结果表明，需要静脉营养的外科患者的伤口愈合反应得到改善。这种改善是在治疗一周后，在营养状况出现明显变化之前看到的。在手术前给予静脉营养比在手术后给予静脉营养对伤口愈合反应的改善更为明显。
The wound healing response was assessed in 90 surgical patients by measuring the accumulation of hydroxypyroline that occurred over a 7 day period, in fine tubes of thin walled GORE‐TEX placed in the subcutaneous layers of the arm. In 47 patients presenting for intravenous nutrition, the wound healing response was less (0·34 ± 0·23 μg hydroxyproline/cm of tubing) than that of 36 normally nourished patients (0·49·0·30 μg/cm; P <0·01). However, it was higher when measured after intravenous feeding had commenced (0·88 ± 0·62 μg/cm; P <0·005). In 29 patients two sequential studies of wound healing were conducted over a 14‐day period of intravenous nutrition. The mean accumulation of hydroxyproline during the first week of intravenous nutrition was 0·36 ± 0·24 μg/cm and this was increased significantly over the second week of feeding to 0·78 ± 0·67 μg/cm; P <0·005. The wound healing response that occurred in wounds made after a period of pre‐operative nutrition was better than that which occurred when only postoperative nutrition had been given (P <0·02). These results show that the wound healing response in surgical patients requiring intravenous nutrition is improved by this treatment. This improvement is seen after only one week of therapy and before there is an obvious change in nutritional status. It also appears that the improved wound healing response is more marked when intravenous nutrition is given before, rather than after the surgical procedure.