Dichloroacetate reduces sympathetic nerve responses to static exercise.
Dichloroacetate reduces sympathetic nerve responses to static exercise.
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二氯乙酸盐可降低交感神经对静态运动的反应。
DOI：
10.1152/ajpheart.1991.261.5.h1653
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Sinoway,L
中科院分区：
文献类型：
--
作者：
Ettinger,S;Gray,K;Whisler,S;Sinoway,L
乳酸被认为是肌肉代谢物受体的兴奋剂。本研究的目的是确定二氯乙酸酯(DCA)抑制乳酸产生是否会减弱前臂静态运动中的肌交感神经活动(MSNA)。DCA可提高丙酮酸脱氢酶水平。因此，对于给定的丙酮酸生成量，形成的乳酸较少。7名受试者在20%最大自主收缩状态下进行前臂静态运动，直到疲劳后握力停止(PHG-CA)(试验1)。然后，受试者接受DCA(35 mg/kg)，并重复锻炼方案(试验2)。我们观察到前臂静脉血乳酸和MSNA的升高有所减弱。试验2的MSNA值在PHG-CA期间比试验1的值低51+/-11%(P<0.01)。在7名对照受试者中，进行了两轮前臂静态训练，并注入了介入性生理盐水。这种干预对运动中的乳酸或MSNA反应没有影响。我们得出结论，DCA可以减弱静态运动对乳酸的反应，这与MSNA反应迟钝有关。
Lactic acid is thought to be a stimulant of muscle metaboreceptors. The goal of the present study was to determine if inhibition of lactic acid production by dichloroacetate (DCA) would attenuate muscle sympathetic nerve activity (MSNA) during static forearm exercise. DCA increases pyruvate dehydrogenase levels. Thus, for a given amount of pyruvate produced, less lactic acid is formed. Seven subjects performed static forearm exercise at 20% maximal voluntary contraction until fatigue followed by posthandgrip circulatory arrest (PHG-CA) (trial.1). Subjects then received DCA (35 mg/kg) and repeated the exercise protocol (trial 2). We observed an attenuated rise in forearm venous lactate and MSNA. The trial 2 MSNA value during PHG-CA was 51 +/- 11% less than the value during trial 1 (P less than 0.01). In seven control subjects, two bouts of static forearm exercise were performed with an intervening saline infusion. This intervention had no effect on lactate or MSNA responses to exercise. We conclude that DCA attenuates lactate responses to static exercise, and this is associated with a blunted MSNA response.