The epidemiology and disease outcomes of human T-lymphotropic virus type II.
The epidemiology and disease outcomes of human T-lymphotropic virus type II.
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发表时间：
2004-07
期刊：
影响因子：
2.2
通讯作者：
Diana F. Roucoux;E. Murphy
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文献类型：
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作者：
Diana F. Roucoux;E. Murphy
人类 T 淋巴细胞病毒 II 型（HTLV-II）是一种人类逆转录病毒，在美洲印第安人和俾格米部落中流行。分子亚型显示出地理隔离，这与该病毒在非洲或南美洲人类中的古老起源一致。最近，美国和欧洲的注射吸毒者已感染 HTLV-II，二次性传播已将低水平的病毒引入普通人群和献血者中。 HTLV-II 与一种称为 HTLV 相关脊髓病/热带痉挛性截瘫 (HAM/TSP) 的痉挛性截瘫有关，也可能与其他神经系统综合征有关。它还与肺炎、支气管炎、关节炎等炎症性疾病的发病率增加有关，并且可能与死亡率增加有关。除少数同时感染HIV的患者出现皮肤淋巴瘤外，没有证据表明HTLV-II会引起淋巴组织增生性疾病。 HTLV-II 和 HIV 共感染尚未被证明可以改变 HIV 疾病的病程，但此类患者的 CD4+ 和 CD8+ 淋巴细胞水平可能发生改变，并且抗逆转录病毒治疗可能会反而增加 HTLV-II 前病毒载量。
Human T-lymphotropic virus type II (HTLV-II) is a human retrovirus which is endemic in Amerindian and pygmy tribes. Molecular subtypes show geographic segregation consistent with an ancient origin of this virus within humans in Africa or South America. More recently, injection drug users in the United States and Europe have become infected with HTLV-II, and secondary sexual transmission has introduced the virus at low levels into the general population and blood donors. HTLV-II has been linked with a spastic paraparesis called HTLV-associated myelopathy / tropical spastic paraparesis (HAM/TSP), and perhaps with other neurological syndromes. It is also associated with an increased incidence of pneumonia and bronchitis, inflammatory conditions such as arthritis, and perhaps with increased mortality. Except for a few cases of cutaneous lymphoma in patients coinfected with HIV, there is no evidence that HTLV-II causes lymphoproliferative disease. HTLV-II and HIV coinfection has not been proven to alter the course of HIV disease, but such patients may have altered levels of CD4+ and CD8+ lymphocytes, and antiretroviral therapy may paradoxically increase HTLV-II proviral load.