Developmental status of preschool children receiving cART: a descriptive cohort study
Developmental status of preschool children receiving cART: a descriptive cohort study
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DOI：
10.1111/cch.12321
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发表时间：
2016-05-01
影响因子：
1.9
通讯作者：
Strehlau, R.
中科院分区：
文献类型：
--
作者：
Potterton, J.;Hilburn, N.;Strehlau, R.
hiv已知会导致婴幼儿的神经发育问题。艾滋病毒对学龄前儿童发展的影响一直没有得到很好的描述。方法本研究在南非约翰内斯堡的一家城市儿科HIV诊所进行。使用了方便样本。采用格里菲斯心理发展量表对68名3至5岁的病情稳定的儿童进行了评估。患有严重艾滋病毒脑病的儿童被排除在研究之外，这使得他们无法参与格里菲斯心理发展量表的项目。结果患儿在平均8.1个月时开始联合抗逆转录病毒治疗（cART）。大多数儿童在病毒学上受到抑制，没有出现消瘦或发育迟缓。严重的全面发育迟缓（z-scores）
BackgroundHIV is known to cause neurodevelopmental problems in infants and young children. The impact of HIV on the development of preschool-age children has been less well described.MethodThe study was conducted at an urban paediatric HIV clinic in Johannesburg, South Africa. A sample of convenience was used. Sixty-eight medically stable children between the ages of 3 and 5years were assessed with the Griffiths Scales of Mental Development. Children were excluded from the study if they had severe HIV encephalopathy, which made it impossible for them to participate in the items on the Griffiths Scales of Mental Development.ResultsThe children had started combination antiretroviral treatment (cART) at a mean age of 8.1months. The majority of the children were virologically suppressed and did not present with wasting or stunting. Severe overall developmental delay (z-scores