Pancreatic function and histoarchitecture in Wistar rats following chronic exposure to Bushfire®: the mitigating role of zinc
Pancreatic function and histoarchitecture in Wistar rats following chronic exposure to Bushfire®: the mitigating role of zinc
复制标题
长期暴露于 Bushfire® 后 Wistar 大鼠的胰腺功能和组织结构：锌的缓解作用
DOI：
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发表时间：
2018
影响因子：
1.6
通讯作者：
Ussa D Tizhe
中科院分区：
文献类型：
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作者：
E. Tizhe;N. Ibrahim;M. Fatihu;S. Ambali;I. Igbokwe;Ussa D Tizhe
目的探讨长期暴露于草甘膦除草剂buhfire®对Wistar大鼠胰腺的毒性病理影响及锌的保护作用。方法以草甘膦为基础的除草剂Buhfire®每天给大鼠染毒14.4~750 mg/kg，锌染毒50或100 mg/kg，并测定血糖和血清胰岛素水平。对组织样本进行组织病理学改变评估。结果草甘膦染毒大鼠血糖和血清胰岛素水平均升高，所有染毒大鼠胰腺腺泡细胞和胰岛均出现中、重度变性改变。这些效应可通过锌的预处理而被阻止。结论长期暴露于草甘膦可改变胰腺功能和组织结构，补锌可减轻这些毒性病理影响。
Objectives To assess the toxicopathologic effects of chronic exposure to the glyphosate-based herbicide Bushfire® on the pancreas of Wistar rats and the protective role of zinc. Methods We exposed the rats to daily doses of 14.4 to 750 mg/kg body weight of the glyphosate-based herbicide Bushfire® and to 50 or 100 mg/kg zinc, and measured blood glucose levels and serum insulin levels. Tissue samples were evaluated for histopathological alterations. Results Levels of both blood glucose and serum insulin increased in glyphosate-exposed rats, and moderate to severe degenerative changes were observed in both glandular pancreatic acinar cells and islets of Langerhans in all rats exposed to glyphosate. These effects were prevented by pretreatment with zinc. Conclusion Chronic exposure to glyphosate can alter pancreatic function and histoarchitecture, but zinc supplementation can mitigate these toxicopathologic effects.
影响因子：
4.2
作者：
Powell, SR
通讯作者：
Powell, SR