Montelukast, an Antagonist of Cysteinyl Leukotriene Signaling, Impairs Burn Wound Healing.
Montelukast, an Antagonist of Cysteinyl Leukotriene Signaling, Impairs Burn Wound Healing.
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孟鲁司特，一种半胱氨酰白三烯信号传导的拮抗剂，损害烧伤伤口愈合。
DOI：
10.1097/prs.0000000000009228
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发表时间：
2022-07-01
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
烧伤是一种严重的损伤，通常与受损的伤口愈合有关。愈合受损是由多种因素引起的，包括伤口部位的炎症反应失调。有趣的是，孟鲁司特，一种半胱氨酰白三烯（cysLT）的拮抗剂和FDA批准用于治疗哮喘和过敏，以前显示出增强切除伤口的愈合和调节局部炎症。在这项研究中，我们研究了孟鲁司特在小鼠烫伤模型中的伤口愈合作用。分析在烧伤后不同时间从孟鲁司特和赋形剂处理的小鼠分离的烧伤伤口组织的伤口面积（n=34- 3 - 6）、上皮再形成（n=14）、炎症（n=8-9）和免疫细胞浸润（n=3-6）以及增殖（n=7-8）。与先前描述的在切除伤口中的有益作用相反，该研究表明孟鲁司特通过损害角质形成细胞和内皮细胞的增殖来延迟烧伤伤口愈合。这在很大程度上独立于伤口部位的炎症反应而发生，表明孟鲁司特在烧伤中特异性地损害伤口愈合的增殖期。不产生白三烯的小鼠的伤口愈合率不受孟鲁司特的影响。孟鲁司特主要通过抑制烧伤后局部细胞的增殖来延缓创面愈合。
Burns are severe injuries often associated with impaired wound healing. Impaired healing is caused by multiple factors including dysregulated inflammatory responses at the wound site. Interestingly, montelukast, an antagonist for cysteinyl leukotrienes (cysLTs) and FDA-approved for treatment of asthma and allergy, was previously shown to enhance healing in excision wounds and to modulate local inflammation. In this study, we examined the effect of montelukast in wound healing in a mouse model of scald burn injury. Burn wound tissues isolated from montelukast- and vehicle-treated mice at various times after burn injury were analyzed for wound areas (n=34–36), re-epithelialization (n=14), inflammation (n=8–9) and immune cell infiltration (n=3–6), and proliferation (n=7–8). In contrast to previously described beneficial effects in excision wounds, this study shows that montelukast delays burn wound healing by impairing the proliferation of keratinocytes and endothelial cells. This occurs largely independently of inflammatory responses at the wound site, suggesting that montelukast impairs specifically the proliferative phase of wound healing, in burns. Wound healing rates in mice in which leukotrienes are not produced were not affected by montelukast. Montelukast delays wound healing mainly by reducing the proliferation of local cells after burn injury.
影响因子：
3.7
作者：
Foster HR;Fuerst E;Lee TH;Cousins DJ;Woszczek G
通讯作者：
Woszczek G