AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.
AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.
复制标题
DOI：
10.1146/annurev-nutr-071812-161148
复制
发表时间：
2014
影响因子：
8.9
通讯作者：
Hardie DG
中科院分区：
文献类型：
--
作者：
Hardie DG
AMP活化蛋白激酶（AMPK）信号通路在真核细胞进化的早期就出现了，当时它似乎参与了对葡萄糖缺乏的反应，或许还参与了对新获得的线粒体输出的监测。由于出现了对葡萄糖内稳态的激素调节，对于哺乳动物细胞来说，葡萄糖缺乏不像单细胞真核生物那么常见。然而，AMPK系统在哺乳动物中得以保留，它通过监测细胞内AMP:ATP和ADP:ATP的比例，并平衡分解代谢和ATP消耗的速率，在细胞自主水平上维持能量内稳态。此外，参与在全身水平维持能量平衡的激素在下丘脑与AMPK相互作用。AMPK可被两种广泛使用的临床药物——二甲双胍和阿司匹林激活，也可被许多植物天然产物激活，这些植物天然产物要么来自传统药物，要么被作为“营养药品”推广。
The AMP-activated protein kinase (AMPK) signaling pathway arose early during evolution of eukaryotic cells, when it appears to have been involved in the response to glucose starvation and perhaps also in monitoring the output of the newly acquired mitochondria. Due to the advent of hormonal regulation of glucose homeostasis, glucose starvation is a less frequent event for mammalian cells than for single-celled eukaryotes. Nevertheless, the AMPK system has been preserved in mammals where, by monitoring cellular AMP:ATP and ADP:ATP ratios and balancing the rates of catabolism and ATP consumption, it maintains energy homeostasis at a cell-autonomous level. In addition, hormones involved in maintaining energy balance at the whole body level interact with AMPK in the hypothalamus. AMPK is activated by two widely used clinical drugs, metformin and aspirin, and also by many natural products of plants that are either derived from traditional medicines or are promoted as “nutraceuticals”.
登录
查看更多内容
影响因子：
3.5
作者：
Chen, Di;Pamu, Sreedhar;Cui, Qiuzhi;Chan, Tak Hang;Dou, Q. Ping
通讯作者：
Dou, Q. Ping
影响因子：
3.5
作者：
CARLING, D;ZAMMIT, VA;HARDIE, DG
通讯作者：
HARDIE, DG
影响因子：
3.5
作者：
Chen, Xu-bing;Zhuang, Jing-jing;Hu, Li-hong
通讯作者：
Hu, Li-hong
DOI：
10.1111/j.1432-1033.1990.tb15293.x
发表时间：
1990-01-12
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
DAVIES, SP;SIM, ATR;HARDIE, DG
通讯作者：
HARDIE, DG
影响因子：
3.6
作者：
Akman, Hasan O.;Sampayo, James N.;Dimauro, Salvatore
通讯作者：
Dimauro, Salvatore