Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
Epstein-Barr virus RNA detection and glandular differentiation in nasopharyngeal carcinoma: report of 2 cases.
复制标题
鼻咽癌EB病毒RNA检测及腺体分化：附2例报告。
DOI：
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发表时间：
2000
影响因子：
4.6
通讯作者：
G. Tallini
中科院分区：
文献类型：
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作者：
D. Jain;V. Parkash;M. Li;J. Gill;J. Crouch;G. Howe;G. Tallini
大多数发生在鼻咽部的肿瘤是鳞状细胞癌或所谓的鼻咽型未分化癌。原发于鼻咽部的腺癌是罕见的，而鼻咽部未分化癌的腺分化至今尚未有报道。我们报告2例鼻咽型未分化癌，在光镜、组织化学、免疫组化及超微结构上显示出明显的腺分化。两种肿瘤的EB病毒潜伏膜蛋白和EB病毒基因组原位杂交在肿瘤的未分化区域和具有腺分化的区域中显示相等的阳性。
Most tumors arising in the nasopharynx are either squamous cell carcinoma or so-called undifferentiated carcinoma of the nasopharyngeal type. Primary adenocarcinomas of the nasopharynx are rare, and glandular differentiation in undifferentiated carcinoma of the nasopharyngeal type has not been reported to date. We report 2 cases of undifferentiated carcinoma of the nasopharyngeal type that show distinct glandular differentiation by light microscopy, histochemistry, immunohistochemistry, and ultrastructure. Both tumors showed equal positivity for Epstein-Barr virus latent membrane protein and in situ hybridization for Epstein-Barr virus genome in the undifferentiated areas of the tumor and those featuring glandular differentiation.
影响因子：
158.5
作者：
PATHMANATHAN, R;PRASAD, U;RAABTRAUB, N
通讯作者：
RAABTRAUB, N