Redox signaling of NF-κB by membrane NAD(P)H oxidases in normal and malignant cells
Redox signaling of NF-κB by membrane NAD(P)H oxidases in normal and malignant cells
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DOI：
10.1007/s00709-002-0059-y
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发表时间：
2003-01-01
期刊：
影响因子：
2.9
通讯作者：
Hoidal, JR
中科院分区：
文献类型：
--
作者：
Brar, SS;Kennedy, TP;Hoidal, JR
与吞噬细胞同源的低活性NAD（P）H氧化酶产生活性氧作为信号中间体的证据正在迅速积累。在这篇综述中，我们讨论了信号传导NAD（P）H氧化酶通过激活氧化还原调节转录因子核因子kappaB部分影响正常和恶性细胞分裂的证据。生长调节NAD（P）H氧化酶在人类气道平滑肌和恶性黑色素瘤中的作用被用作例子。
Evidence is rapidly accumulating that low-activity NAD(P)H oxidases homologous to that in phagocytic cells generate reactive oxygen species as signaling intermediates. In this review we discuss evidence that signaling NAD(P)H oxidases in part influence normal and malignant cell division by activating the redox-regulated transcription factor nuclear factor kappaB. The roles of growth-regulatory NAD(P)H oxidases in human airway smooth muscle and malignant melanoma are used as examples.