Determination of the electrical conductivity of human liver metastases: impact on therapy planning in the radiofrequency ablation of liver tumors
Determination of the electrical conductivity of human liver metastases: impact on therapy planning in the radiofrequency ablation of liver tumors
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DOI：
10.1177/0284185116639765
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发表时间：
2017-02
期刊：
影响因子：
1.3
通讯作者：
U. Zurbuchen;F. Poch;O. Gemeinhardt;M. Kreis;S. Niehues;Janis L Vahldieck;K. Lehmann
中科院分区：
文献类型：
--
作者：
U. Zurbuchen;F. Poch;O. Gemeinhardt;M. Kreis;S. Niehues;Janis L Vahldieck;K. Lehmann
背景放射性消融用于诱导热坏死治疗肝转移瘤。肝转移瘤的比电导率对组织内的热形成和所导致的肿瘤消融具有明显的影响。目的测定结直肠癌肝转移灶和手术切除的无瘤肝组织的电导率σ。材料与方法采用可切除的结直肠癌肝转移患者的手术标本进行测量（转移灶大小<30 mm）。使用四针测量探针测定共5名患者的人结直肠肝转移瘤（n = 8）和无肿瘤肝组织（n = 5）的电导率σ。所有测量均在470 kHz下进行，这是射频消融的相关频率。还测量了组织温度。肝切除术按照常见的外科标准进行。切除后立即在手术室进行测量。结果结直肠癌肝转移灶中位温度为35.1℃时，电导率σ为0.57S/m;无瘤肝组织中位温度为34.9℃时，电导率σ为0.35S/m。肿瘤组织的电导率显著高于无瘤肝组织（P = 0.005）。两组之间的组织温度无差异（P = 0.883）。结论在470 kHz频率下，结直肠癌肝转移灶的电导率明显高于正常肝组织。
Background Radiofrequency ablation is used to induce thermal necrosis in the treatment of liver metastases. The specific electrical conductivity of a liver metastasis has a distinct influence on the heat formation and resulting tumor ablation within the tissue. Purpose To examine the electrical conductivity σ of human colorectal liver metastases and of tumor-free liver tissue in surgical specimens. Material and Methods Surgical specimens from patients with resectable colorectal liver metastases were used for measurements (size of metastases <30 mm). A four-needle measuring probe was used to determine the electrical conductivity σ of human colorectal liver metastasis (n = 8) and tumor-free liver tissue (n = 5) in a total of five patients. All measurements were performed at 470 kHz, which is the relevant frequency for radiofrequency ablation. The tissue temperature was also measured. Hepatic resections were performed in accordance with common surgical standards. Measurements were performed in the operating theater immediately after resection. Results The median electrical conductivity σ was 0.57 S/m in human colorectal liver metastases at a median temperature of 35.1℃ and 0.35 S/m in tumor-free liver tissue at a median temperature of 34.9℃. The electrical conductivity was significantly higher in tumor tissue than in tumor-free liver tissue (P = 0.005). There were no differences in tissue temperature between the two groups (P = 0.883). Conclusion The electrical conductivity is significantly higher in human colorectal liver metastases than in tumor-free liver tissue at a frequency of 470 kHz.