The UK national evaluation of the development and impact of Early Intervention Services (the National EDEN studies): study rationale, design and baseline characteristics
The UK national evaluation of the development and impact of Early Intervention Services (the National EDEN studies): study rationale, design and baseline characteristics
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DOI：
10.1111/eip.12007
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发表时间：
2014-02-01
影响因子：
2
通讯作者：
Marshall, Max
中科院分区：
文献类型：
--
作者：
Birchwood, Max;Lester, Helen;Marshall, Max
目的：国家EDEN旨在评估英格兰各地区不同配置的早期干预服务（EIS）的实施情况及其对关键结果的影响，并开发一个患者结果差异模型，该模型包括未治疗精神病（DUP）持续时间的关键变量，对EIS模型的忠实度和服务参与。在患者出院时，对该队列进行了两年的随访，以观察变化的稳定性和出院环境的影响。方法：一项纵向队列研究的患者首次发作的精神病，由EIS管理的六个服务在英格兰。患者在入院后12个月随访，出院后随访2年。测量DUP、精神病、社会功能和复发情况。长期监测环境信息系统的用户和护理者体验；每个环境影响报告书对国家指导方针的忠实程度也是如此。对服务的使用进行卫生经济评估。结果：1027人同意研究，其中75%在12个月时成功随访，几乎100%的治疗、复发、恢复和服务使用数据。结论：国家EDEN是在EIS下接受治疗的年轻精神病患者中最大的队列研究。它将能够明确地表明，英国在EI方面的这项重大投资是否在实践中为其用户实现了有意义的变化，并提供关于谁在这种方法下做得好，谁做得不好的指示，以及任何改进的长期稳定性。
Aims: National EDEN aims to evaluate the implementation and impact on key outcomes of somewhat differently configured Early Intervention Services (EIS) across sites in England and to develop a model of variance in patient outcomes that includes key variables of duration of untreated psychosis (DUP), fidelity to the EIS model and service engagement. The cohort is being followed up for two further years as patients are discharged, to observe the stability of change and the impact of the discharge settings.Methods: A longitudinal cohort study of patients with a first episode of a psychosis, managed by EIS in six services across England. Patients are followed up 12 months after inception, then up to 2 years following discharge. Measures of DUP, psychosis, social functioning and relapse were taken. User and carer experience of EIS were monitored over time; as was the fidelity of each EIS to national guidelines. Service use is costed for a health economic evaluation.Results: 1027 people consented to the study of which 75% were successfully followed up at 12 months, with almost 100% data on treatment, relapse and recovery and service use.Conclusions: National EDEN is the largest cohort study of young people with psychosis receiving care under EIS. It will be able definitively to indicate whether this major investment in the United Kingdom in EI is achieving meaningful change for its users in practice and provide indications concerning who does well under this approach and who does not, and the long-term stability of any improvements.