The stereochemical requirement for protein kinase C activation by 3-methyldiglycerides matches that found in naturally occurring tumor promoters aplysiatoxins.
The stereochemical requirement for protein kinase C activation by 3-methyldiglycerides matches that found in naturally occurring tumor promoters aplysiatoxins.
复制标题
3-甲基二甘油酯激活蛋白激酶 C 的立体化学要求与天然存在的肿瘤促进剂海兔毒素中发现的相匹配。
DOI：
10.1016/0014-5793(90)81364-t
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发表时间：
1990
期刊：
影响因子：
3.5
通讯作者：
Rando,RR
中科院分区：
文献类型：
--
作者：
Kong,F;Kishi,Y;Perez-Sala,D;Rando,RR
Protein kinase C is stereospecifically activated by,sn-1,2-(S)-diglycerides. A second chiral center was introduced into the diglycerides by preparing the 3-methyl derivatives. The activation of protein kinase C was also stereospecific with respect to the new chiral center established at the C3 position of the methylated diglycerides. The stereospecificity of protein kinase C directed towards the C2 and C3 positions of the diglycerides is matched in the analogous C29 and C30 stereocenters of the tumor promoting debromoaplysiatoxins. This finding strengthens the view that the structurally diverse tumor promotors contain the embedded diglyceride-like pharmacophore.
