Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors
Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors
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DOI：
10.1021/acs.jnatprod.9b01169
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发表时间：
2020-08-28
影响因子：
5.1
通讯作者：
Stien, Didier
中科院分区：
文献类型：
--
作者：
Peyrat, Laure-Anne;Eparvier, Veronique;Stien, Didier
Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1-13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC50 values in the 10 to 20 mu M range without cytotoxicity. None inhibited Zika virus NS5 protein.
