Prediction of major depression in Japanese adults: Somatic manifestation of depression in annual health examinations
Prediction of major depression in Japanese adults: Somatic manifestation of depression in annual health examinations
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DOI：
10.1016/j.jad.2005.09.010
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发表时间：
2006-01-01
影响因子：
6.6
通讯作者：
Yano, E
中科院分区：
文献类型：
--
作者：
Nakao, M;Yano, E
背景：本研究探讨了每年体检中发现的躯体症状是否可以预测下一年的重度抑郁症。方法：研究对象为在某研究所参加年度体检的1027名非重度抑郁症工作人员(706名男性，平均年龄35岁)。根据《精神疾病诊断和统计手册》第四版(DSM-IV)的半结构化采访，所有人都是日本人，在接受采访时发现他们没有患上严重的抑郁症。所有受试者都完成了一份包含12项主要躯体症状的自填式问卷。采用同样的DSM-IV诊断重度抑郁症的访谈，计算抑郁和躯体症状、体检项目、健康相关生活方式等基线变量对下一年重度抑郁症的预测优势比。对于四种躯体症状(疲倦、腰背痛、头晕和恶心)，那些在基线时抱怨每种躯体症状的人比那些没有抱怨的人的患病率更高(均P<；0.05)。多因素Logistic回归分析显示，下腰痛和基线头晕是下一年重度抑郁症的独立危险因素[优势比(OR)分别为3.2(95%可信区间)，3.2(1.1，8.9)和6.0(1.8，20.1)]。限制：抑郁症的躯体表现可能是一种文化局限的现象，其结果可能只适用于日本工人。结论：每年体检报告的躯体症状可能是预测重度抑郁症的有用指标。(C)2005 Elsevier B.V.保留所有权利。
Background: The present study examined whether somatic symptoms found in annual health examinations, could be predictive of major depression in the ensuing year.Method: Subjects analyzed were 1027 non-major-depressive workers (706 men, mean age 35) attending annual health examinations at a research institute. All were Japanese and found not to be suffering from major depression when interviewed, according to the semi-structured interviews of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). A self-administered questionnaire containing items relating to twelve major somatic symptoms was completed by all the subjects. The same DSM-IV interviews for the diagnosis of major depression were conducted to calculate the odds ratio of baseline variables for depressive and somatic symptoms, physical examination items, and health-related life-styles for the prediction of major depression in the ensuing year.Results: The prevalence of major depression in the ensuing year was 2.5%. For four somatic symptoms (fatigue, lower back pain, dizziness, and nausea), the prevalence was higher (all p < 0.05) in those who complained of each somatic symptom at baseline than in those who did not. Furthermore, the multiple logistic regression analysis indicated that lower back pain and dizziness at baseline were independent risk factors of major depression in the ensuing year [odds ratio (95% confidence intervals), 3.2 (1.1, 8.9) and 6.0 (1.8, 20.1), respectively).Limitations: It is possible that somatic manifestations of depression are culturally bound phenomena and results might be generalizable only to Japanese workers.Conclusion: Somatic symptoms reported at annual health examinations may be useful indicators for predicting major depression. (c) 2005 Elsevier B.V. All rights reserved.