Postoperative pulmonary complications after preoperative chemoradiation for esophageal carcinoma: Correlation with pulmonary dose-volume histogram parameters
Postoperative pulmonary complications after preoperative chemoradiation for esophageal carcinoma: Correlation with pulmonary dose-volume histogram parameters
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DOI：
10.1016/s0360-3016(03)01373-7
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发表时间：
2003-12-01
影响因子：
7
通讯作者：
Komaki, R
中科院分区：
文献类型：
--
作者：
Lee, HK;Vaporciyan, AA;Komaki, R
目的：探讨食管癌低剂量伴化疗肺部比例与术后肺部并发症发生的关系。方法：从1998年至2002年在我院接受食管癌术前放化疗的117例患者中，我们选择了61例可获得完整肺剂量-容量直方图（DVH）数据的患者，分析该组患者肺炎和急性呼吸窘迫综合征（ARDS）的发生率。所有患者均接受同步放化疗，39例患者在同步放化疗前还接受了诱导化疗。中位年龄62岁，中位放疗剂量45 Gy。记录各肺DVH中接受至少10gy （V10）、15gy （V15）和20gy （V20）的肺体积百分比。结果：61例患者中有11例（18%）出现肺部并发症，其中2例因肺炎进展死亡。当肺部V10大于等于40%时，肺部并发症发生率更高（35% vs 8%, p = 0.014）。
Purpose: To clarify the relationship between the percentage of lung receiving low radiation doses with concurrent chemotherapy and the occurrence of postoperative pulmonary complications in the treatment of esophageal carcinoma.Methods: From 117 patients who underwent preoperative chemoradiation for esophageal cancer at our institution between 1998 and 2002, we selected 61 patients for whom complete pulmonary dose-volume histogram (DVH) data were available and analyzed the incidence of pneumonia and acute respiratory distress syndrome (ARDS) in this group. All patients received concurrent chemoradiation therapy, and 39 patients also received induction chemotherapy before concurrent chemoradiation. The median age was 62 years, and the median radiotherapy dose was 45 Gy. The percentage of lung volume receiving at least 10 Gy (V10), 15 Gy (V15), and 20 Gy (V20) were recorded from each pulmonary DVH.Results: Eleven (18%) of the 61 patients had pulmonary complications, 2 of whom died after progression of pneumonia. Pulmonary complications were noted more often (35% vs. 8%, p = 0.014) when the pulmonary V10 was greater than or equal to40% vs.