An observational longitudinal study to evaluate miction, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer
An observational longitudinal study to evaluate miction, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer
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DOI：
10.1111/j.1525-1438.2006.00461.x
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发表时间：
2006-05-01
影响因子：
4.8
通讯作者：
Kenter, G. G.
中科院分区：
文献类型：
--
作者：
Pieterse, Q. D.;Maas, C. P.;Kenter, G. G.
本研究的目的是评估 I-IIA 期宫颈癌根治性子宫切除术联合或不联合辅助放疗后的行为、排便和性行为问题。这项研究包括一项自我报告的膀胱、排便和性问题的观察性纵向研究，并具有基线评分。九十四名女性参与了这项研究。年龄匹配的对照组由 224 名女性组成。在整个 24 个月的随访过程中，与对照组及其治疗前的情况相比，患者对性功能的负面影响明显更大。这些问题包括润滑不足、阴道狭窄、短小、阴唇周围无知觉、性交困难和性不满意。治疗后 12 个月内，与对照组相比，患者明显更多地抱怨很少或没有排尿冲动和腹泻。辅助放疗不会增加膀胱功能障碍、结直肠蠕动障碍和性功能的风险。我们的结论是，用于治疗早期宫颈癌的根治性子宫切除术与主要对性功能的不良影响有关。
The objective of this study was to evaluate the problems with miction, defecation, and sexuality after a radical hysterectomy with or without adjuvant radiotherapy for the treatment of cervical cancer stage I-IIA. This study included an observational longitudinal study of self-reported bladder, defecation, and sexual problems with a baseline score. Ninety-four women were included in the study. An age-matched control group consisted of 224 women. The patients showed significantly more negative effects on sexual function compared with both the controls and their situation before the treatment throughout 24 months of follow-up. The problems included less lubrication, a narrow and short vagina, senseless areas around the labia, dyspareunia, and sexual dissatisfaction. Up to 12 months after the treatment, the patients complained significantly more of little or no urge to urinate and diarrhea as compared with the controls. Adjuvant radiotherapy did not increase the risk of bladder dysfunction, colorectal motility disorders, and sexual functions. We conclude that a radical hysterectomy for the treatment of early-stage cervical carcinoma is associated with adverse effects mainly on sexual functioning.