Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2′-deoxyuridines fluorometrically respond to hybridization

Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2′-deoxyuridines fluorometrically respond to hybridization
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DOI:
10.1039/b705805e
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发表时间:
2007-01-01
影响因子:
3.2
通讯作者:
Ghorbani-Choghamarani, Arash
Ghorbani-Choghamarani, Arash
中科院分区:
化学3区
文献类型:
--
作者:
Hudson, Robert H. E.;Ghorbani-Choghamarani, Arash

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选定的 2'-脱氧尿苷的 5-乙炔基衍生物显示出对杂交的荧光响应,并选择性地与腺嘌呤碱基配对,同时保持双链体稳定性。
Selected 5-ethynyl derivatives of 2'-deoxyuridine are shown to fluorometrically respond to hybridization and selectively base-pair to adenine whilst maintaining duplex stability.