Pseudocystic Foveal Cavitation in Tamoxifen Retinopathy
Pseudocystic Foveal Cavitation in Tamoxifen Retinopathy
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DOI：
10.1016/j.ajo.2014.02.046
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发表时间：
2014-06-01
影响因子：
4.2
通讯作者：
Rosenfeld, Philip J.
中科院分区：
文献类型：
--
作者：
Doshi, Rishi R.;Fortun, Jorge A.;Rosenfeld, Philip J.
PURPOSE: To present 3 cases of tamoxifen-induced foveal cavitation and review previous prospective and cross-sectional studies.DESIGN: Observational case series.METHODS: Retrospective analysis of patients presenting to a single institution with evidence of tamoxifen-induced maculopathy.RESULTS: Three patients presented with pseudocystic foveal cavitation similar in appearance to macular telangiectasia type 2 on spectral-domain optical coherence tomography (SD OCT) imaging.CONCLUSIONS: Tamoxifen maculopathy is characterized by cavitation in the central macula with or without typical cystoid macular edema. Pathogenesis involves toxicity to retinal Muller cells. It can occur with low daily and cumulative doses of the drug, and in the absence of subjective visual complaints or crystalline retinopathy. Prospective research with SD OCT imaging will be required to gain a more accurate estimate of the incidence of tamoxifen retinopathy. (C) 2014 by Elsevier Inc. All rights reserved.
