Functional Connectivity in the Default Network During Resting State is Preserved in a Vegetative but Not in a Brain Dead Patient
Functional Connectivity in the Default Network During Resting State is Preserved in a Vegetative but Not in a Brain Dead Patient
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DOI：
10.1002/hbm.20672
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发表时间：
2009-08-01
影响因子：
4.8
通讯作者：
Laureys, S.
中科院分区：
文献类型：
--
作者：
Boly, M.;Tshibanda, L.;Laureys, S.
最近对清醒健康受试者的功能磁共振血氧水平依赖(BOLD)信号的自发波动的研究表明，在功能定义的神经解剖网络之间存在相干波动。然而，这些自发的大胆波动的功能意义仍然鲜为人知。通过3T功能磁共振成像，我们显示缺乏皮质-丘脑BOLD功能连接(即后扣带/楔前皮质和内侧丘脑之间)，但保留了默认网络内的皮质-皮质连接，这例植物状态(VS)在心肺骤停2.5年后被广泛的行为和临床评估所证实。在VS患者中，与年龄匹配的对照组一样，也可以观察到扣带回/楔前叶后部与先前发现的任务阳性皮质网络之间的反相关关系。与对照组相比，VS患者的相关性和反相关性均显著降低。在脑死亡患者身上的类似方法没有显示出任何这样的长距离功能连接。我们的结论是，以前在健康清醒的人脑中发现的一些缓慢连贯的大胆波动可以在活着但不知情的患者中发现，因此不太可能是唯一的，因为有意识的思维正在进行修改。未来的研究需要给出VS患者群体中默认网络连接的完整特征。《猎脑地图》30：2393-2400,2009。(C)2009年Wiley-Liss，Inc.
Recent Studies On Spontaneous fluctuations in the functional MRI blood oxygen level-dependent (BOLD) signal in awake healthy subjects showed the presence of coherent fluctuations among functionally defined neuroanatomical networks. However, the functional significance of these spontaneous BOLD fluctuations remains poorly understood. By means of 3 T functional MRI, we demonstrate absent cortico-thalamic BOLD functional connectivity (i.e. between posterior cingulate/precuneal cortex and medial thalamus), but preserved cortico-cortical connectivity within the default network in a case of vegetative state (VS) Studied 2.5 years following cardio-respiratory arrest, as documented by extensive behavioral and paraclinical assessments. In the VS patient, as in age-matched controls, anticorrelations could also be observed between posterior cingulate/precuneus and a previously identified task-positive cortical network. Both correlations and anticorrelations were significantly reduced in VS as compared to controls. A similar approach in a brain dead patient did not show any such long-distance functional connectivity. We conclude that some slow coherent BOLD fluctuations previously identified in healthy awake human brain can be found in alive but unaware patients, and are thus unlikely to be uniquely due to ongoing modifications of conscious thoughts. Future studies are needed to give a full characterization of default network connectivity in the VS patients Population. Hunt Brain Mapp 30:2393-2400, 2009. (c) 2009 Wiley-Liss, Inc.