Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide
Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide
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DOI：
10.1002/anie.201509282
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发表时间：
2016-01-22
影响因子：
16.6
通讯作者：
Qing, Feng-Ling
中科院分区：
文献类型：
--
作者：
Lin, Qing-Yu;Xu, Xiu-Hua;Qing, Feng-Ling
溴二氟甲基溴化鏻单独用作二氟卡宾的前体。在此，一个前所未有的可见光诱导的烯烃与溴化二氟甲基鏻使用水和THF作为氢源的二氟甲基化烷烃的合成。这种二氟甲基化反应的特点是反应条件温和，试剂易得，官能团耐受性好。
Bromodifluoromethylphosphonium bromide was solely used as the precursor of difluorocarbene. Herein, an unprecedented visible-light-induced hydrodifluoromethylation of alkenes with bromodifluoromethylphosphonium bromide using H2O and THF as hydrogen sources for the synthesis of difluoromethylated alkanes is described. This difluoromethylation is characterized by mild reaction conditions, ready availability of reagents, and excellent functional-group tolerance.