A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.
A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.
复制标题
MMP9 中的单核苷酸多态性与类固醇诱导的股骨头坏死风险降低相关。
DOI：
10.18632/oncotarget.12034
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发表时间：
2016-10-18
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
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作者：
Du J;Liu W;Jin T;Zhao Z;Bai R;Xue H;Chen J;Sun M;Zhang X;Wang G;Wang J
股骨头坏死是一种常见的髋关节疾病，激素性股骨头坏死占绝大多数。在此，我们检测了来自中国北方的285名激素诱导的ONFH患者和507名健康对照者的MPP2和MPP9基因中8个先前鉴定的单核苷酸多态性（SNP），以确定这些SNP是否与发生激素诱导的ONFH的风险相关。卡方检验和遗传模型和单倍型分析用于评估关联。MMP 9中的rs2274755 SNP与等位基因、显性和加性模型中类固醇诱导的ONFH风险降低相关。此外，“CGC”MMP 9单倍型与激素诱导的ONFH风险降低0.69倍相关。虽然需要更多的、更大规模的人群研究来证实这些发现，但我们的研究结果首次揭示了在北方中国人群中，rs2274755位点的MMP 9 SNP与类固醇诱导的ONFH风险降低之间的关联。
Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the “CGC” MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.