Is plaque formation in the common carotid artery representative for plaque formation and luminal stenosis in other atherosclerotic peripheral arteries? A post mortem study
Is plaque formation in the common carotid artery representative for plaque formation and luminal stenosis in other atherosclerotic peripheral arteries? A post mortem study
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DOI：
10.1016/s0021-9150(97)00255-4
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发表时间：
1998-03-01
期刊：
影响因子：
5.3
通讯作者：
Borst, C
中科院分区：
文献类型：
--
作者：
Pasterkamp, G;Schoneveld, AH;Borst, C
动脉粥样硬化的颈动脉很容易进行无创双工检查。本死后研究的目的是检查颈总动脉斑块积聚和管腔狭窄是否代表其他外周动脉粥样硬化斑块积聚和管腔狭窄。从240条动脉（24个人）中定期获得3765个横截面。研究了颈总动脉、股总动脉、髂总动脉、髂外动脉和肾动脉等5种外周动脉。在每个横截面上测量管腔面积、血管面积、斑块面积和最大斑块厚度。对于每个位置，计算管腔狭窄的百分比和相对斑块面积。相对斑块面积定义为斑块占血管面积的百分比。颈总动脉斑块相对面积百分比或最大斑块厚度百分比与其他外周动脉斑块相对面积百分比呈弱相关（r = 0.41-0.59）。颈总动脉斑块堆积和管腔狭窄与其他外周动脉管腔狭窄比例均无相关性（P < 0.05）。我们得出结论，颈总动脉斑块面积与斑块面积弱相关，而与其他外周动脉管腔狭窄无关。(C) 1998爱思唯尔科学爱尔兰有限公司版权所有。
The atherosclerotic carotid artery is easily accessible for non-invasive duplex investigation. The aim of the present post mortem study was to examine whether plaque accumulation and luminal stenosis in the common carotid artery is representative for atherosclerotic plaque accumulation and luminal stenosis in other peripheral arteries. A total of 3765 cross-sections were obtained at regular intervals from 240 arteries (24 individuals). Five types of peripheral arteries were investigated: common carotid, femoral, common iliac, external iliac and renal arteries. In each cross-section, the lumen area, vessel area, plaque area and maximal plaque thickness was measured. For each location, the percentage luminal stenosis and relative plaque area was calculated. Relative plaque area was defined as the percentage of the vessel area which was occupied by plaque. Weak correlations (r = 0.41-0.59) were observed between percentage relative plaque area or maximal plaque thickness in the common carotid artery and percentage relative plaque area in other peripheral arteries. Neither plaque accumulation nor luminal stenosis in the common carotid artery correlated with the percentage luminal stenosis in other peripheral arteries (P > 0.05). We conclude that plaque area in the common carotid artery is weakly correlated with plaque area and not correlated with luminal stenosis in other peripheral arteries. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.