Swine as biomedical animal model for T-cell research-Success and potential for transmittable and non-transmittable human diseases
Swine as biomedical animal model for T-cell research-Success and potential for transmittable and non-transmittable human diseases
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DOI：
10.1016/j.molimm.2021.04.004
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发表时间：
2021-04-17
影响因子：
3.6
通讯作者：
Kaser，Tobias
中科院分区：
文献类型：
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作者：
Kaser，Tobias
猪是生物医学研究中最重要的大型动物模型之一。猪作为食用动物，可作为研究的游离细胞和组织来源，对人类疾病具有高度易感性，因此猪也是3R原则和One Health研究的绝佳选择。猪模型以前最大的限制因素之一是其有限的免疫工具箱。然而，在过去的十年里，这个工具箱已经有了很大的改进，包括研究猪T细胞的能力。本文综述了以T细胞为重点的生物医学研究的猪模型。它首先将猪模型与更常用的小鼠和非人灵长类动物模型进行了对比，然后描述了目前表征和扩展我们对猪T细胞的知识的能力。此后，它不仅反映了以前的生物医学T细胞研究，而且还扩展到更深入的T细胞分析可能对生物医学研究产生重大影响的领域。虽然前者应该告知猪的生物医学T细胞研究的成功，但后者应该激励猪T细胞研究人员与其他领域的研究人员合作-如营养，过敏，癌症，移植，传染病或疫苗开发。
Swine is biologically one of the most relevant large animal models for biomedical research. With its use as food animal that can be exploited as a free cell and tissue source for research and its high susceptibility to human diseases, swine additionally represent an excellent option for both the 3R principle and One Health research. One of the previously most limiting factors of the pig model was its arguably limited immunological toolbox. Yet, in the last decade, this toolbox has vastly improved including the ability to study porcine T-cells. This review summarizes the swine model for biomedical research with focus on T cells. It first contrasts the swine model to the more commonly used mouse and non-human primate model before describing the current capabilities to characterize and extend our knowledge on porcine T cells. Thereafter, it not only reflects on previous biomedical T-cell research but also extends into areas in which more in-depth T-cell analyses could strongly benefit biomedical research. While the former should inform on the successes of biomedical T-cell research in swine, the latter shall inspire swine T-cell researchers to find collaborations with researchers working in other areas – such as nutrition, allergy, cancer, transplantation, infectious diseases, or vaccine development.