Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma.
Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma.
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DOI：
10.1002/jso.23982
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发表时间：
2015-08
影响因子：
2.5
通讯作者：
Pawlik TM
中科院分区：
文献类型：
--
作者：
Bagante F;Tran TB;Postlewait LM;Maithel SK;Wang TS;Evans DB;Hatzaras I;Shenoy R;Phay JE;Keplinger K;Fields RC;Jin LX;Weber SM;Salem A;Sicklick JK;Gad S;Yopp AC;Mansour JC;Duh QY;Seiser N;Solorzano CC;Kiernan CM;Votanopoulos KI;Levine EA;Poultsides GA;Pawlik TM
全身炎症反应可能与肿瘤进展相关。我们试图分析嗜中性淋巴细胞比率（NLR）和血小板淋巴细胞比率（PLR）对肾上腺皮质癌（ACC）手术患者的无复发生存期（RFS）和疾病特异性生存期（DSS）的影响。从多中心数据库中确定了接受ACC手术的患者。临界值5和190分别定义为NLR和PLR升高，并评估长期结局。84例ACC患者中，29例（34.0%）NLR >5，PLR >190者32例（40.5%）。NLR和PLR与较大的肿瘤相关（NLR >5：≤ 5 cm，0% vs. >5 cm，39.7%; PLR >190：≤ 5 cm，0% vs. >5 cm，45.7%），以及需要切除其他器官（NLR >5：其他器官切除48.8% vs.未切除20.9%; PLR >190：其他器官切除25.0% vs.未切除56.4%）（均P <0.05）。5年RFS与NLR（NLR ≤ 5，14.2% vs. NLR>5，10.5%）和PLR（PLR ≤190：19.4% vs. PLR >190：5.2%）升高相关（均P <0.05）。在多变量生存分析中，PLR仍然是RFS的预测因子（HR 1.72），而NLR与DSS（HR 2.21）和RFS（HR 1.99）相关（均P <0.05）。免疫标记物如NLR和PLR可能有助于对ACC手术后的预后进行分层。
The systemic inflammatory response may be associated with tumor progression. We sought to analyze the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and disease-specific survival (DSS) among patients who underwent surgery for adrenocortical carcinoma (ACC). Patients undergoing surgery for ACC were identified from a multi-center database. Cut-off values of 5 and 190 were defined as elevated NLR and PLR, respectively, and long-term outcome was assessed. Among 84 patients with ACC, 29 (34.%) had NLR >5 while 32 (40.5%) had PLR >190. NLR and PLR were associated with larger tumors (NLR >5: ≤ 5 cm, 0% vs. >5 cm, 39.7%; PLR >190: ≤ 5cm, 0% vs. >5 cm, 45.7%), as well as need to resect of other organs (NLR >5: other organ resected 48.8% vs. not resected 20.9%; PLR >190: other organ resected 25.0% vs. not resected 56.4%)(all P <0.05). Five-year RFS was associated with an elevated NLR (NLR ≤ 5, 14.2% vs. NLR>5, 10.5%) and PLR (PLR ≤190: 19.4% vs. PLR >190: 5.2%) (both P <0.05). On multivariate survival analyses, PLR remained a predictor of RFS (HR 1.72), while NLR was associated with both DSS (HR 2.21) and RFS (HR 1.99) (both P <0.05). Immune markers such as NLR and PLR may be useful to stratify patients with regards to prognosis following surgery for ACC.