Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder
Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder
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DOI：
10.1034/j.1600-0447.2003.00070.x
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发表时间：
2003-04-01
影响因子：
6.7
通讯作者：
Lee, MC
中科院分区：
文献类型：
--
作者：
Kang, DH;Kwon, JS;Lee, MC
目的：方法：采用正电子发射断层扫描（PET）技术，对10例强迫症（OCD）患者治疗前后的脑葡萄糖代谢率进行检测。结果：治疗后，患者在多个脑区表现出显著的（P < 0.005，双尾）局部代谢改变，涉及额-皮层下回路和顶-小脑网络。特别是壳核、小脑和海马的代谢变化与Rey-Osterrieth复杂图形测验（RCFT.Conclusion）的即时和延迟回忆分数的改善显著相关。这些结果表明，额叶-皮层下和顶叶-小脑回路的代谢变化可能是强迫症患者认知改善的基础。
Objective: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD).Method: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [(18) F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments.Results: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT).Conclusion: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.