Progress of labor in women induced with misoprostol versus the Foley catheter.

Progress of labor in women induced with misoprostol versus the Foley catheter.
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DOI:
10.1016/j.ajog.2013.05.005
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发表时间:
2013-09
影响因子:
9.8
通讯作者:
Cahill, Alison G.
Cahill, Alison G.
中科院分区:
医学1区
文献类型:
--
作者:
Tuuli, Methodius G.;Keegan, Mary B.;Odibo, Anthony O.;Roehl, Kimberly;Macones, George A.;Cahill, Alison G.

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评估并比较米索前列醇与Foley导管加催产素诱导的分娩持续时间和进展。我们进行了一项回顾性队列研究,对617例连续足月妊娠的产程进展进行了研究,这些妊娠分别采用米索前列醇(n=503)或Foley导管加催产素(n=114)诱导,并完成了第一产程。在调整了母亲肥胖和出生体重的多变量区间删失回归模型中,比较了整个队列的产程时间和进展,并按产次分层。重复测量分析与9次多项式建模被用来构建平均劳动力曲线。米索前列醇诱导的妇女的分娩总持续时间与Foley导管的中位数相比无显著差异(中位数持续时间为1至10 cm:12 vs 14.2小时,p=0.19)。Foley导管从1 cm进展到4 cm更快(中位数:3.4 vs 5.6小时,p<0.01),而从4 cm进展到10 cm较慢(中位数:6.3 vs 3.6小时,p<0.01)。产程曲线显示米索前列醇在宫颈扩张约4cm时从潜伏产程过渡到主动产程,Foley导管在宫颈扩张6cm时从潜伏产程过渡到主动产程。除了在经产妇女中使用Foley导管的产程持续时间较短外,在未经产和经产妇女中注意到类似的一般模式。使用Foley导管引产与更快的初始宫颈扩张相关,但与米索前列醇相比,过渡到活跃分娩发生得更晚。这些差异应在引产管理中加以考虑。
To estimate and compare the duration and progress of labor in women induced with misoprostol versus Foley catheter plus oxytocin. We performed a retrospective cohort study of labor progress among 617 consecutive term pregnancies induced with misoprostol (n=503) or Foley catheter plus oxytocin (n=114) who completed the first stage of labor. Labor duration and progress in the entire cohort, and stratified by parity, were compared in multivariable interval-censored regression models adjusting for maternal obesity and birth weight. Repeated-measures analysis with 9th degree polynomial modeling was used to construct average labor curves. Total duration of labor was not significantly different in women induced with misoprostol compared to the Foley catheter median (median duration from 1 to 10 cm: 12 versus 14.2 hours, p=0.19). Progress from 1 to 4 cm was more rapid with the Foley catheter (median: 3.4 versus 5.6 hours, p<0.01), while progress from 4 to 10 cm was slower (median: 6.3 versus 3.6 hours, p<0.01). Labor curves demonstrated transition from latent to active labor at about 4 cm cervical dilatation with misoprostol and at 6cm for the Foley catheter. Similar general patterns were noted for nulliparous and multiparous women, except for a shorter duration of labor with the Foley catheter among multiparous women. Induction of labor with the Foley catheter is associated with more rapid initial cervical dilation, but transition to active labor occurs later compared to misoprostol. These differences should be considered in the management of induced labor.
DOI: 10.1080/01443610500231450
发表时间: 2005-08-01
期刊: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
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