Maternal immunisation: collaborating with mother nature
Maternal immunisation: collaborating with mother nature
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DOI：
10.1016/s1473-3099(17)30229-3
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发表时间：
2017-07-01
影响因子：
56.3
通讯作者：
Kollmann, Tobias R.
中科院分区：
文献类型：
--
作者：
Marchant, Arnaud;Sadarangani, Manish;Kollmann, Tobias R.
母亲免疫接种有可能大大降低出生后传染病的发病率和死亡率。妊娠期间破伤风、流感和百日咳免疫接种的成功导致考虑额外的母体免疫接种策略，以预防B组链球菌和呼吸道合胞病毒感染等。然而，关于孕产妇免疫接种的免疫生物学知识的许多差距阻碍了这种成功的公共卫生干预措施的最佳设计和应用。因此，我们进行了创新的景观分析，以确定研究重点。通过对已发表文献的回顾、与疫苗开发者和监管机构的磋商以及一个聚集了多个孕产妇免疫接种倡议（B群链球菌、呼吸道合胞病毒、百日咳和流感）专家的协作研讨会，确定了关键主题。最后，一项全球在线调查根据专家关于知识差距重要性和相关性的意见，对已查明的知识差距进行了优先排序。在这里，我们提出了这一全球景观分析的结果，并讨论了确定的研究差距。
Maternal immunisation has the potential to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza, and pertussis immunisation during pregnancy has led to consideration of additional maternal immunisation strategies to prevent group B streptococcus and respiratory syncytial virus infections, among others. However, many gaps in knowledge regarding the immunobiology of maternal immunisation prevent the optimal design and application of this successful public health intervention. Therefore, we did an innovative landscape analysis to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop that gathered experts across several maternal immunisation initiatives-group B streptococcus, respiratory syncytial virus, pertussis, and influenza. Finally, a global online survey prioritised the identified knowledge gaps on the basis of expert opinion about their importance and relevance. Here we present the results of this worldwide landscape analysis and discuss the identified research gaps.