Kidney donors live longer
Kidney donors live longer
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DOI：
10.1097/00007890-199710150-00007
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发表时间：
1997-10-15
期刊：
影响因子：
6.2
通讯作者：
Groth, CG
中科院分区：
文献类型：
--
作者：
FehrmanEkholm, I;Elinder, CG;Groth, CG
背景活体供肾移植中一个非常重要的问题是供肾对供肾者是否安全（1，2，3，4）。本研究的目的是检查肾脏捐献者的存活率和死亡原因，并评估那些20多年前捐献肾脏的人的肾功能。从1964年到1994年底，在斯德哥尔摩共进行了459例活体供肾切除术。通过使用国家登记册，对居住在瑞典的所有430名献血者进行了追踪。采用Kaplan-Meier法分析供者存活率，采用Hakulinens法计算预期存活率，并以全国死亡率为基础。41例受试者在捐献后15个月至31年内死亡，死亡模式与一般人群相似，大多数死于心血管疾病和恶性肿瘤。经过20年的随访，85%的供体存活，而预期的存活率为66%，因此供体组的存活率高出29%。> 20年前献血的献血者（46 - 91岁）中有三分之一患有高血压。随着年龄的增长，肾功能恶化，与正常健康受试者相似。75岁及以上供者的平均肾小球滤过率为48 ml/min/1.73 m2。捐肾似乎并不构成任何长期风险。捐赠者的存活率较高可能是因为只有健康的人才被接受活体肾脏捐赠。
Background. A very important issue in living kidney donor transplantation is whether the donation is safe for the donor(1,2,3,4). The aim of this study was to examine survival and causes of death in kidney donors and to assess the renal function in those who had donated a kidney more than 20 years ago,Methods. A total of 459 living donor nephrectomies were performed in Stockholm from 1964 until the end of 1994. By using national registers, all 430 donors living in Sweden were traced. Donor survival was analysed using the Kaplan-Meier method, Expected survival was computed using the Hakulinens method and was based on national mortality rates.Results. Forty-one subjects had died between 15 months and 31 years after the donation, The mortality pattern was similar to that ill the general population, the majority dying of cardiovascular diseases and malignancies. After 20 years of follow-up, 85% of the donors were alive, whereas the expected survival rate was 66%, Survival was thus 29% better in the donor group. One third of the donors (aged 46-91 years) who had donated >20 years ago had hypertension. There was a deterioration in the renal function with increasing age, similar to what is seen among normal healthy subjects. The average glomerular filtration rate in donors aged 75 years and over was 48 ml/min/1.73 m(2).Conclusions. To donate a kidney does not seem to constitute any long-term risk. The better survival among donors is probably due to the fact that only healthy persons are accepted for living kidney donation.