Increased intratumor concentration of fluorescein-isothiocyanate-labeled neocarzinostatin in rats under angiotensin-induced hypertension.
Increased intratumor concentration of fluorescein-isothiocyanate-labeled neocarzinostatin in rats under angiotensin-induced hypertension.
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DOI：
10.1111/j.1349-7006.1988.tb00050.x
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发表时间：
1988-07
期刊：
影响因子：
--
通讯作者：
Suzuki M
中科院分区：
文献类型：
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作者：
Abe I;Hori K;Saito S;Tanda S;Li YL;Suzuki M
基于血管紧张素（AT）诱导的高血压下肿瘤组织血流量选择性增加的观察结果，在雄性Donryu大鼠中检查了肿瘤和正常组织中药物浓度的变化。在药物注射后20分钟内，AT诱导的高血压组中异硫氰酸荧光素标记的新制癌素的肿瘤内浓度约为对照组的2倍。然而，在荷瘤大鼠的正常器官或未受累器官中，与组织血流观察结果预期的一样，与对照组相比，实验组中未观察到明显增加。目前的研究支持这样的假设，即先前报道的AT诱导的高血压下化疗的抗癌作用增强是由于药物递送的肿瘤选择性增强。
On the basis of the observation that the tumor tissue blood flow selectively increases under angiotensin (AT)‐induced hypertension, the change of the drug concentration in the tumor and normal tissues was examined in male Donryu rats. The intratumor concentration of fluorescein isothiocyanate‐labeled neocarzinostatin was about 2‐fold higher in the AT‐induced hypertension group than in the control up to 20 min after the drug injection. In the normal organs or the uninvolved organs of the tumor‐bearing rats, however, no clear increase was seen in the experimental group compared with the control, as anticipated from the observation of the tissue blood flow. The present study supports the hypothesis that the enhanced anticancer effect in chemotherapy under AT‐induced hypertension formerly reported is due to the tumor‐selective enhancement of the drug delivery.