COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea.
COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea.
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通过对鼻、喉和气管进行有针对性的水合作用，可减轻COVID-19症状。
DOI：
10.1038/s41598-022-08609-y
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发表时间：
2022-03-29
影响因子：
4.6
通讯作者：
Edwards DA
中科院分区：
文献类型：
--
作者：
George CE;Scheuch G;Seifart U;Inbaraj LR;Chandrasingh S;Nair IK;Hickey AJ;Barer MR;Fletcher E;Field RD;Salzman J;Moelis N;Ausiello D;Edwards DA
上呼吸道的脱水会增加呼吸道疾病的风险，从COVID-19到哮喘和COPD。我们在涉及德国、美国和印度464名人类受试者的人类志愿者研究中发现，在老年（n = 357）、BMI升高（n = 148）、剧烈运动（n = 20）和SARS-CoV-2感染（n = 87）的脱水相关状态下，呼吸液滴生成增加多达4个数量级，而福尔斯则因鼻子水合而跌倒，喉和气管的高渗盐。我们还发现，在运动诱导的气道脱水的方案中，通过富含钙的盐的气道水合作用相对于未治疗的对照增加了氧合（P <0.05）。在一项针对COVID-19阳性受试者（n = 40）的随机对照研究中，每天三次给予富钙高渗盐（活性）抑制了51% ± 11%的呼吸液滴生成，并在治疗三天内将氧饱和度提高了48.08% ± 9.61%（P <0.001），而鼻盐水对照组没有观察到变化。活动组的自我报告症状显著下降，而对照组没有下降。上呼吸道的水合作用似乎很有希望成为降低COVID-19等呼吸道疾病风险的非药物方法。
Dehydration of the upper airways increases risks of respiratory diseases from COVID-19 to asthma and COPD. We find in human volunteer studies involving 464 human subjects in Germany, the US, and India that respiratory droplet generation increases by up to 4 orders of magnitude in dehydration-associated states of advanced age (n = 357), elevated BMI-age (n = 148), strenuous exercise (n = 20) and SARS-CoV-2 infection (n = 87), and falls with hydration of the nose, larynx and trachea by calcium-rich hypertonic salts. We also find in a protocol of exercise-induced airway dehydration that hydration of the airways by calcium-rich salts increases oxygenation relative to a non-treatment control (P < 0.05). In a random control study of COVID-19 positive subjects (n = 40), thrice-a-day delivery of the calcium-rich hypertonic salts (active) suppressed respiratory droplet generation by 51% ± 11% and increased oxygen saturation over three days of treatment by 48.08% ± 9.61% (P < 0.001), while no changes were observed in the nasal-saline control group. Self-reported symptoms significantly declined in the active group and did not decline in the control group. Hydration of the upper airways appears promising as a non-drug approach for reducing risks of respiratory diseases such as COVID-19.
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影响因子：
64.5
作者：
Hou, Yixuan J.;Okuda, Kenichi;Baric, Ralph S.
通讯作者：
Baric, Ralph S.
DOI：
10.1073/pnas.1902840116
发表时间：
2019-05-28
影响因子：
11.1
作者：
Kudo, Eriko;Song, Eric;Iwasaki, Akiko
通讯作者：
Iwasaki, Akiko
影响因子：
7.3
作者：
Kumar S;Çalışkan DM;Janowski J;Faist A;Conrad BCG;Lange J;Ludwig S;Brunotte L
通讯作者：
Brunotte L
十个科学原因支持SARS-COV-2的机载传播。
DOI：
10.1016/s0140-6736(21)00869-2
发表时间：
2021-05-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Greenhalgh T;Jimenez JL;Prather KA;Tufekci Z;Fisman D;Schooley R
通讯作者：
Schooley R
影响因子：
3.7
作者：
Etzold, Merlin A.;Linden, P. F.;Worster, M. Grae
通讯作者：
Worster, M. Grae