Respiratory syncytial virus entry inhibitors targeting the F protein.
Respiratory syncytial virus entry inhibitors targeting the F protein.
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针对 F 蛋白的呼吸道合胞病毒侵入抑制剂
DOI：
10.3390/v5010211
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发表时间：
2013-01-16
期刊：
影响因子：
--
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Sun Z;Pan Y;Jiang S;Lu L
人呼吸道合胞病毒（RSV）是婴幼儿呼吸道感染的主要病毒病原，也是一些老年人和高危成人慢性肺部疾病和严重免疫功能低下者呼吸道感染的主要病原。到目前为止，尚未报道特异性抗RSV治疗剂或有效的抗RSV疫苗。只有一种人源化单克隆抗体帕利珠单抗已被批准用于高危婴儿预防RSV感染。利巴韦林是目前唯一被批准用于治疗RSV感染的药物，但其非特异性抗RSV活性、毒性作用和相对较高的成本限制了其临床应用。因此，迫切需要开发新的有效的抗RSV治疗剂。RSV包膜糖蛋白F在RSV与宿主细胞融合和进入宿主细胞中起重要作用，因此，作为开发RSV进入抑制剂的有吸引力的靶标。本文综述了F蛋白的结构、功能及以F蛋白为靶点的RSV进入抑制剂的研究进展。
Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised. So far, no specific anti-RSV therapeutics or effective anti-RSV vaccines have been reported. Only one humanized monoclonal antibody, Palivizumab, has been approved for use in high-risk infants to prevent RSV infection. Ribavirin is the only drug licensed for therapy of RSV infection, but its clinical use is limited by its nonspecific anti-RSV activity, toxic effect, and relatively high cost. Therefore, development of novel effective anti-RSV therapeutics is urgently needed. The RSV envelope glycoprotein F plays an important role in RSV fusion with, and entry into, the host cell and, consequently, serves as an attractive target for developing RSV entry inhibitors. This article reviews advances made in studies of the structure and function of the F protein and the development of RSV entry inhibitors targeting it.
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DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
7.3
作者：
Bonfanti, Jean-Francois;Meyer, Christophe;Andries, Koen
通讯作者：
Andries, Koen
影响因子：
4.9
作者：
Cianci, C;Yu, KL;Krystal, M
通讯作者：
Krystal, M
影响因子：
3.1
作者：
Jiang, SB;Lin, K;Debnath, AK
通讯作者：
Debnath, AK
影响因子：
5.4
作者：
Chaiwatpongsakorn, Supranee;Epand, Raquel F.;Peeples, Mark E.
通讯作者：
Peeples, Mark E.