Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction.
Global MEG Resting State Functional Connectivity in Children with Autism and Sensory Processing Dysfunction.
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自闭症和感觉处理功能障碍儿童的全球 MEG 静息态功能连接。
DOI：
10.1101/2024.01.26.577499
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Marco,ElysaJ
中科院分区：
文献类型：
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作者：
Demopoulos,Carly;Jesson,Xuan;Gerdes,MollyRae;Jurigova,BarboraG;Hinkley,LeightonB;Ranasinghe,KamaliniG;Desai,Shivani;Honma,Susanne;Mizuiri,Danielle;Findlay,Anne;Nagarajan,SrikantanS;Marco,ElysaJ
感觉处理功能障碍不仅影响大多数自闭症谱系障碍（ASD）患者，而且至少5%的非ASD儿童也会经历感觉处理功能障碍。我们对感觉功能障碍和静息态大脑活动之间关系的理解仍在不断发展。本研究使用脑磁图（MEG）比较了8-12岁自闭症谱系障碍（ASD; N=18）儿童、不符合ASD标准的感觉处理功能障碍（SPD; N=18）儿童和典型发育对照参与者（TDC; N=24）的神经振荡行为的长距离静息状态功能连接。在α和β频带中进行功能连接性分析，已知这与感觉信息处理有关。功能连接和感官能力和功能连接之间的关联组差异进行了检查。ASD和SPD组之间的功能连接差异的独特模式仅在β带中发现，而不是在α带中。在α和β带中，ASD和SPD队列与TDC队列不同。躯体感觉皮层β-带功能连接与触觉处理能力相关，而高阶听觉皮层α-带功能连接与听觉处理能力相关。这些研究结果表明，与感觉处理能力相关的SPD和ASD的不同的远程神经同步性改变。神经同步性测量可以作为ASD和SPD的潜在敏感生物标志物。
Sensory processing dysfunction not only affects most individuals with autism spectrum disorder (ASD), but at least 5% of children without ASD also experience dysfunctional sensory processing. Our understanding of the relationship between sensory dysfunction and resting state brain activity is still emerging. This study compared long-range resting state functional connectivity of neural oscillatory behavior in children aged 8–12 years with autism spectrum disorder (ASD; N=18), those with sensory processing dysfunction (SPD; N=18) who do not meet ASD criteria, and typically developing control participants (TDC; N=24) using magnetoencephalography (MEG). Functional connectivity analyses were performed in the alpha and beta frequency bands, which are known to be implicated in sensory information processing. Group differences in functional connectivity and associations between sensory abilities and functional connectivity were examined. Distinct patterns of functional connectivity differences between ASD and SPD groups were found only in the beta band, but not in the alpha band. In both alpha and beta bands, ASD and SPD cohorts differed from the TDC cohort. Somatosensory cortical beta-band functional connectivity was associated with tactile processing abilities, while higher-order auditory cortical alpha-band functional connectivity was associated with auditory processing abilities. These findings demonstrate distinct long-range neural synchrony alterations in SPD and ASD that are associated with sensory processing abilities. Neural synchrony measures could serve as potential sensitive biomarkers for ASD and SPD.