Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography
Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography
复制标题
用于高效磁共振血管造影的氧化铁纳米板的表面和界面工程
DOI：
10.1021/nn507193f
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发表时间：
2015-03-01
期刊：
影响因子：
17.1
通讯作者：
Gao, Jinhao
中科院分区：
文献类型：
--
作者：
Zhou, Zijian;Wu, Changqiang;Gao, Jinhao
使用钆基分子造影剂的磁共振血管造影术具有诊断窗口短、分辨率相对较低和毒性风险的缺点。考虑到金属中心和周围质子之间的化学交换，具有合适表面和界面特征的磁性纳米颗粒可用作替代的T-1造影剂。在这里，我们报告的氧化铁纳米片的表面结构的工程，以提高T-1对比度的能力，通过暴露的富金属Fe 3 O 4（100）方面和嵌入的Gd 2 O3簇之间的协同效应。纳米片在宽范围的磁场中显示出突出的T-1对比度，其Δ Pr（1）值高达61.5 MM-1 s（-1）。此外，通过两性离子分子在纳米生物界面上的工程化调整了纳米片的体内行为，用于具有稳态采集窗口、超高血管细节分辨率和低毒性的高效磁共振血管造影。本研究为生物成像应用中各种用途的MRI造影剂的复杂设计提供了一个强大的工具。
Magnetic resonance angiography using gadolinium-based molecular contrast agents suffers from short diagnostic window; relatively low resolution and risk of toxicity. Taking into account the chemical exchange between metal Centers and surrounding protons; magnetic nanoparticles with suitable surface and interfacial features may serve as alternative T-1 contrast agents. Herein, we report the engineering on surface structure of iron oxide nanoplates to boost T-1 contrast ability through synergistic effects between exposed metal-rich Fe3O4(100) facets and embedded Gd2O3 clusters. The nanoplates show prominent T-1 contrast in a wide range of magnetic fields with an ultrahigh r(1) value up to 61.5 MM-1 s(-1). Moreover, engineering on nanobio interface through zwitterionic molecules adjusts the in vivo behaviors of nanoplates for highly efficient magnetic resonance angiography with steady-state acquisition Window, Superhigh resolution in vascular details, and low toxicity. This study provides a powerful tool for sophisticated design of MRI contrast agents for diverse use in bioimaging applications.