Neural correlates of interoception: Effects of interoceptive focus and relationship to dimensional measures of body awareness.
Neural correlates of interoception: Effects of interoceptive focus and relationship to dimensional measures of body awareness.
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DOI：
10.1002/hbm.23811
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发表时间：
2017-12
影响因子：
4.8
通讯作者：
Burdick KE
中科院分区：
文献类型：
--
作者：
Stern ER;Grimaldi SJ;Muratore A;Murrough J;Leibu E;Fleysher L;Goodman WK;Burdick KE
内感受被定义为对身体生理状况的感知，而内感受性（IS）表征了个体对内在感觉的自我报告意识。信息系统是一个多维结构，不仅包括意识到感觉的倾向，还包括感觉是如何被解释、调节和用来告知行为的，不同的维度与健康和疾病的不同方面有关。在此，我们研究了健康个体在关注心跳和皮肤温度时的内感受的神经机制，并使用多维内感受意识量表（MAIA）研究了内感受时的神经活动与自我报告IS的个体差异之间的关系。与先前的研究一致，内感受激活了一个包括脑岛和感觉运动区，但也包括枕叶、颞叶和前额叶皮层的网络。在脑岛、感觉运动区、枕叶皮质和边缘区发现了基于内感受焦点（心跳与皮肤温度）的差异。MAIA维度的因子分析显示，我们的数据集中有3个可分离的IS成分，其中只有一个与内感受期间的神经活动有关。第三个因素的得分降低，反映了控制身体感觉注意力的能力下降，分散注意力和担心厌恶感觉的倾向增加，这与许多与内感受有关的区域的活跃程度增加有关，包括岛叶、感觉运动、前扣带和颞叶皮层。这些数据表明，自我评定的内感受性与监测身体状态的区域激活的改变有关，这可能与内感受异常相关的疾病有关。
Interoception has been defined as the sensing of the physiological condition of the body, with interoceptive sensibility (IS) characterizing an individual's self-reported awareness of internal sensation. IS is a multidimensional construct including not only the tendency to be aware of sensation, but also how sensations are interpreted, regulated, and used to inform behavior, with different dimensions relating to different aspects of health and disease. Here we investigated neural mechanisms of interoception when healthy individuals attended to their heartbeat and skin temperature, and examined the relationship between neural activity during interoception and individual differences in self-reported IS using the Multidimensional Scale of Interoceptive Awareness (MAIA). Consistent with prior work, interoception activated a network involving insula and sensorimotor regions but also including occipital, temporal, and prefrontal cortex. Differences based on interoceptive focus (heartbeat vs. skin temperature) were found in insula, sensorimotor regions, occipital cortex, and limbic areas. Factor analysis of MAIA dimensions revealed 3 dissociable components of IS in our dataset, only one of which was related to neural activity during interoception. Reduced scores on the third factor, which reflected reduced ability to control attention to body sensation and increased tendency to distract from and worry about aversive sensations, was associated with greater activation in many of the same regions as those involved in interoception, including insula, sensorimotor, anterior cingulate, and temporal cortex. These data suggest that self-rated interoceptive sensibility is related to altered activation in regions involved in monitoring body state, which has implications for disorders associated with abnormality of interoception.
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影响因子：
2.6
作者：
Garfinkel, Sarah N.;Tiley, Claire;Critchley, Hugo D.
通讯作者：
Critchley, Hugo D.
影响因子：
3.8
作者：
Farb, Norman;Daubenmier, Jennifer;Mehling, Wolf E.
通讯作者：
Mehling, Wolf E.
DOI：
10.1080/10401230500295339
发表时间：
2005-10-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Abramowitz, Jonathan S
通讯作者：
Abramowitz, Jonathan S
影响因子：
3.3
作者：
Cameron, OG
通讯作者：
Cameron, OG
影响因子：
2.5
作者：
CERVERO, F;CONNELL, LA
通讯作者：
CONNELL, LA