Symmetry of callosal information transfer in schizophrenia: a preliminary study
Symmetry of callosal information transfer in schizophrenia: a preliminary study
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DOI：
10.1016/j.schres.2004.08.007
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发表时间：
2005-05-01
影响因子：
4.5
通讯作者：
Kirk, IJ
中科院分区：
文献类型：
--
作者：
Barnett, KJ;Corballis, MC;Kirk, IJ
目的：虽然有大量证据表明精神分裂症存在左半球功能障碍和半球间转移缺陷，但右半球很少涉及。本研究使用 128 通道 EEG 来评估精神分裂症患者中是否存在正常个体中发现的半球间转移不对称性，以及这是否可能表明右半球功能障碍。方法：记录 13 名精神分裂症男性和 13 名对照者对左视野 (LVF)、右视野 (RVF) 或双侧 (BVF) 刺激的简单反应时间 (RT)。同时记录128通道脑电图。通过比较刺激对侧和同侧半球中 N160 EP 分量的延迟来计算每个方向的半球间传输时间 (IHTT)。结果：虽然对照组显示从右半球到左半球的信息传输更快，但精神分裂症组中不存在这种不对称性，精神分裂症组还表现出右半球 N160 振幅的伴随下降。结论：结果解释为提及精神分裂症患者右半球快速传导有髓鞘轴突的丧失。 (C) 2004 Elsevier B.V. 保留所有权利。
Objective: While there is much evidence to suggest left hemisphere dysfunction and interhemispheric transfer deficits in schizophrenia, the right hemisphere is rarely implicated. This study uses 128-channel EEG to assess whether asymmetry of interhemispheric transfer found in normal individuals is present in those with schizophrenia, and whether this might point to a right-hemisphere dysfunction.Methods: Simple reaction time (RT) was recorded to stimuli presented to the left visual field (LVF), right visual field (RVF) or bilaterally (BVF) in 13 males with schizophrenia and 13 controls. 128-Channel EEG was simultaneously recorded. Interhemispheric transfer time (IHTT) in each direction was calculated by comparing the latencies of N160 EP components in the hemispheres contralateral and ipsilateral to stimulation.Results: While controls showed faster information transfer from the right-to-left hemisphere, this asymmetry was not present in the schizophrenia group who also exhibited a concomitant decrease in the amplitude of the N160 in the right hemisphere.Conclusions: Results are interpreted with reference to a loss of rapidly conducting myelinated axons in the right hemisphere in schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.