Evidence for a novel bursting mechanism in rodent trigeminal neurons
Evidence for a novel bursting mechanism in rodent trigeminal neurons
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DOI：
10.1016/s0006-3495(98)77504-6
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发表时间：
1998-07-01
影响因子：
3.4
通讯作者：
Garfinkel, A
中科院分区：
文献类型：
--
作者：
Del Negro, CA;Hsiao, CF;Garfinkel, A
我们研究了啮齿动物三叉神经元的爆发行为。生物系统中运行的基本机制是根据数学模型的可测试预测确定的。三叉神经运动神经元中的爆发活动与在稳态电流-电压关系中采用负斜率电阻区域的传统机制一致（Smith，T.G.1975.Nature.253：450-452）。然而，三叉神经中间神经元的爆发动力学与传统机制不一致，并且可以通过利用与尖峰阈值相关的独特稳定性特性的新爆发模型更有效地解释（Baer, S. M., T. Emeux, and J. Rinzel. 1989. SIAM J. Appl. Math. 49:55-71）。
We investigated bursting behavior in rodent trigeminal neurons. The essential mechanisms operating in the biological systems were determined based on testable predictions of mathematical models. Bursting activity in trigeminal motoneurons is consistent with a traditional mechanism employing a region of negative slope resistance in the steady-state current-voltage relationship (Smith, T. G. 1975. Nature. 253:450-452). However, the bursting dynamics of trigeminal interneurons is inconsistent with the traditional mechanisms, and is far more effectively explained by a new model of bursting that exploits the unique stability properties associated with spike threshold (Baer, S. M., T. Emeux, and J. Rinzel. 1989. SIAM J. Appl. Math. 49:55-71).