Review on the role of glutathione on oxidative stress and infertility.
Review on the role of glutathione on oxidative stress and infertility.
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DOI：
10.5935/1518-0557.20180003
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发表时间：
2018-03-01
期刊：
影响因子：
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通讯作者：
Christiania O
中科院分区：
文献类型：
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作者：
Adeoye O;Olawumi J;Opeyemi A;Christiania O
不孕症是一个全球性的健康问题，也是已婚夫妇中最紧张的情况之一。即使不是致命的，它已被描述为一个激进的改变生活的问题，它带来了重大的心理创伤。不孕症可以由各种问题引起，有时无法确定原因。氧化应激是由活性氧（ROS）和保护性抗氧化剂之间的不平衡引起的，它影响着男性和女性的整个生殖寿命。ROS可以调节细胞功能，氧化应激可以扰乱细胞内环境，导致病变细胞或危及细胞存活。在正常情况下，抗氧化剂的作用是对抗ROS的产生，清除现有的自由基，促进ROS诱导的细胞结构损伤的修复。在受控水平下，氧化应激促进某些生理生殖功能，但在较高水平下，它涉及生殖道的病理过程，导致不孕症和不良妊娠结局。由于高水平的活性氧和低抗氧化状态与导致不育的疾病有关，因此基于增强生殖微环境的耗尽的抗氧化防御的策略的治疗是直观的。麸质是一种天然的身体抗氧化剂，有助于保护所有其他抗氧化剂。它存在于雄性和雌性配子中，其水平差异很大。本研究综述了氧化应激在男性和女性不孕症中的作用，以及谷胱甘肽对不孕症的抗氧化作用。
Infertility is a global health problem and it is one of the most stressful conditions amongst married couples. Even though not lethal, it has been described as a radical life changing problem that carries with it significant psychological trauma. Infertility can be caused by various problems and sometimes it is not possible to establish a cause. Oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) and protective antioxidants, influences the entire reproductive lifespan of men and women. ROS can modulate cellular functions, and oxidative stress can disturb the intracellular milieu, resulting in diseased cells or endanger cell survival. Under normal conditions, antioxidants act to oppose ROS production, scavenging existing free radicals and promoting the repair of ROS-induced damage to cell structures. At controlled levels, oxidative stress facilitates some physiological reproductive functions but at higher levels it is implicated in pathological processes in the reproductive tract that contribute to infertility and poor pregnancy outcomes. As high levels of reactive oxygen species and low antioxidant status have been implicated in conditions contributing to infertility, treatment based on strategies to boost the exhausted antioxidant defense of the reproductive microenvironment is intuitive. Glutathione is a natural body antioxidant, which helps preserve all other antioxidants. It is present in both the male and female gametes and its level varies widely. This study reviews the role oxidative stress plays in both male and female infertility, and the antioxidant action of glutathione on infertility.