Biomaterials for Regenerative Medicine
Biomaterials for Regenerative Medicine
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再生医学生物材料
DOI：
10.1002/adhm.202001920
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发表时间：
2020
影响因子：
10
通讯作者：
Antonios G. Mikos
中科院分区：
文献类型：
--
作者：
Shengmin Zhang;Antonios G. Mikos
生物织物和生物材料科学的最新进展已经能够更准确地再现复杂的组织微环境，并且现代组织工程方法通过在一系列建筑尺度上结合多种材料以及通过整合影响细胞行为的生化和物理组分来扩展传统范例。本特刊重点介绍了用于促进功能性骨、软骨、肌肉和皮肤再生的广泛策略，并概述了推动该领域发展的各种研究。骨组织修复的一个值得注意的策略是使用改性钛或钛合金植入物。为了提高这些材料的成骨能力并降低感染风险，可以将双功能元素添加到微米或纳米结构的表面氧化物涂层中，以改变表面的物理化学性质。综述概述了这一领域的进展，包括在这个问题上的Kaifu霍等。（2000681）。骨组织修复的另一个有趣的策略是设计与骨组织损伤后形成的骨折血肿相互作用的生物材料。Yin Xiao等人在一篇综述文章中研究了生物材料对凝血和血肿特征的影响。（2000726），并提供了通过调节血肿性质来增强骨生成的观点。同样，新生骨组织的新血管形成对于组织向内生长和修复至关重要。Shengmin Zhang等人的一篇原创文章强调了选择性激光烧结技术的杠杆作用，以生产多孔聚己内酯/羟基磷灰石支架，当VEGF固定在支架表面时，该支架可增强血管形成和骨再生（2000727）。
Recent advances in biofabrication and biomaterials science have enabled more accurate recapitulation of complex tissue microenvironments, and modern tissue engineering approaches expand upon the traditional paradigm by incorporating multiple materials over a range of architectural scales and by integrating biochemical and physical components that influence cellular behavior. This special issue highlights a breadth of strategies used to promote the regeneration of functional bone, cartilage, muscle, and skin and provides an overview of the diverse research that is driving the field forward.One notable strategy for bone tissue repair is the use of modified Ti or Ti-alloy implants. To increase the osteogenic capabilities of these materials and reduce the risk of infection, bifunctional elements can be added to micro-or nano-structured surface oxide coatings to alter surface physicochemical properties. A review outlining this progress in this field is included in this issue by Kaifu Huo et al.(2000681). Another interesting tactic for bone tissue repair is designing biomaterials that interact with the fracture hematoma formed upon injury to bone tissue. The effects of biomaterials on blood coagulation and hematoma characteristics are examined in a review article by Yin Xiao et al.(2000726), and perspectives on enhancing osteogenesis by regulating hematoma properties are provided. Similarly, neovascularization of de novo bone tissue is critical for tissue ingrowth and repair. An original article by Shengmin Zhang et al. highlights the leverage of a selective laser sintering technique to produce a porous polycaprolactone/hydroxyapatite scaffold that enhances blood vessel formation and bone regeneration when VEGF is immobilized on the scaffold surface (2000727).