Single Molecule Discrimination of Heteropolytungstates and Their Isomers in Solution with a Nanometer-Scale Pore
Single Molecule Discrimination of Heteropolytungstates and Their Isomers in Solution with a Nanometer-Scale Pore
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DOI：
10.1021/jacs.6b02917
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发表时间：
2016-06-15
影响因子：
15
通讯作者：
Balijepalli, Arvind
中科院分区：
文献类型：
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作者：
Ettedgui, Jessica;Kasianowicz, John J.;Balijepalli, Arvind
我们报告了一种新的方法来识别金属纳米簇（聚氧乙烯酸盐结构）在溶液中的单分子限制使用纳米级孔。该技术允许测量具有比常规分析化学工具低超过2个数量级的分析物浓度的聚氧乙烯酸盐。此外，磷钨酸的pH依赖性的结构变化与蛋白质nanpp或es测量和验证与NMR。我们进一步证明该方法也可以区分[PW_9O_34]（9-）结构异构体。结果表明，这种技术可以作为传统方法的补充方法。
We report a new method to identify metallic nanoclusters (polyoxometalate structures) in solution at the single molecule limit using a nanometerscale pore. The technique allows the measurement of polyoxometalates with over 2 orders of magnitude lower analyte concentration than conventional analytical chemistry tools. Furthermore, pH-dependent structural changes in phosphotungstic acid are measured with protein nanpp or es and validated with NMR. We further demonstrate that the method can also discriminate [PW9O34](9-) structural isomers. The results suggest this technique can serve as a complementary approach to traditional methods.