Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity
Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity
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DOI：
10.1073/pnas.95.6.2950
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发表时间：
1998-03-17
影响因子：
11.1
通讯作者：
Salisbury, JL
中科院分区：
文献类型：
--
作者：
Lingle, WL;Lutz, WH;Salisbury, JL
中心体在维持细胞极性和细胞周期进程中起重要作用，它决定了分裂间期和有丝分裂期微管的数量、极性和组织。通过检查一组35个高级别的人乳腺肿瘤，我们发现，腺癌细胞的中心体通常显示异常的结构，异常的蛋白磷酸化，并增加微管成核能力相比，正常乳腺上皮和间质组织的中心体。这些结构性和功能性中心体缺陷对于理解实体瘤中基因组不稳定性和细胞极性丧失的机制具有重要意义。
The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.