Enhancement-mode ion-based transistor as a comprehensive interface and real-time processing unit for in vivo electrophysiology
Enhancement-mode ion-based transistor as a comprehensive interface and real-time processing unit for in vivo electrophysiology
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DOI：
10.1038/s41563-020-0638-3
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发表时间：
2020-03-16
期刊：
影响因子：
41.2
通讯作者：
Khodagholy, Dion
中科院分区：
文献类型：
--
作者：
Cea, Claudia;Spyropoulos, George D.;Khodagholy, Dion
生物电子设备必须快速而灵敏地与神经组织产生的快速、低振幅信号相互作用。它们还应具有生物相容性和柔软性，并应在生理环境中表现出长期稳定性。在这里，我们开发了一种增强模式，内部离子门控有机电化学晶体管（e-IGT），基于可逆氧化还原反应和导电聚合物通道内的水合离子储层，使其能够长期稳定运行并缩短离子传递时间。E-IGT瞬态响应取决于空穴而不是离子迁移率，并与高跨导相结合，导致增益带宽产品比其他离子基晶体管高出几个数量级。我们使用这些晶体管来获取广泛的电生理信号，包括神经动作电位的体内记录，并创建软的、生物相容的、长期可植入的神经处理单元，用于实时检测癫痫放电。E-IGTs为长期植入的生物电子学提供了一种安全、可靠和高性能的构建模块，具有单个神经元尺度的时空分辨率。在增强模式下工作的内部离子门控有机电化学晶体管被证明可以记录体内的电生理信号，其速度和灵敏度可以检测单个神经元的动作电位。
Bioelectronic devices must be fast and sensitive to interact with the rapid, low-amplitude signals generated by neural tissue. They should also be biocompatible and soft, and should exhibit long-term stability in physiologic environments. Here, we develop an enhancement-mode, internal ion-gated organic electrochemical transistor (e-IGT) based on a reversible redox reaction and hydrated ion reservoirs within the conducting polymer channel, which enable long-term stable operation and shortened ion transit time. E-IGT transient responses depend on hole rather than ion mobility, and combine with high transconductance to result in a gain-bandwidth product that is several orders of magnitude above that of other ion-based transistors. We used these transistors to acquire a wide range of electrophysiological signals, including in vivo recording of neural action potentials, and to create soft, biocompatible, long-term implantable neural processing units for the real-time detection of epileptic discharges. E-IGTs offer a safe, reliable and high-performance building block for chronically implanted bioelectronics, with a spatiotemporal resolution at the scale of individual neurons.Internal ion-gated organic electrochemical transistors operating in enhancement mode are shown to record electrophysiological signals in vivo, with a speed and sensitivity that enable the detection of action potentials from individual neurons.