How Do Meningeal Lymphatic Vessels Drain the CNS?

How Do Meningeal Lymphatic Vessels Drain the CNS?
复制标题

DOI:
10.1016/j.tins.2016.07.001
复制
发表时间:
2016-09
影响因子:
15.9
通讯作者:
Kipnis J
Kipnis J
中科院分区:
医学1区
文献类型:
--
作者:
Raper D;Louveau A;Kipnis J

文献摘要

参考文献

被引文献

相似文献

神经和免疫系统之间的许多相互作用在生理和病理状态下都是活跃的,最近随着脑膜淋巴系统的发现而变得更加清楚,该脑膜淋巴系统能够将液体、免疫细胞和大分子从CNS运送到引流的颈深淋巴结。然而,脑膜淋巴管系统的确切定位和从CSF到淋巴管的引流路径仍然知之甚少。在这里,我们讨论了外周和中枢神经系统淋巴管之间的潜在差异,并检查了中枢神经系统淋巴引流的所谓机制,沿着这些如何适应既定的脑脊液流动模式。
The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells and macromolecules from the CNS to the draining deep cervical lymph nodes. The exact localization of the meningeal lymphatic vasculature and the path of drainage from the CSF to the lymphatics remain, however, poorly understood. Here we discuss the potential differences between peripheral and CNS lymphatic vessels and examine the purported mechanisms of CNS lymphatic drainage, along with how these may fit into established patterns of CSF flow.
DOI: 10.1038/srep04422
发表时间: 2014-03-21
期刊: Scientific reports
影响因子: 4.6
作者:
Harris MG;Hulseberg P;Ling C;Karman J;Clarkson BD;Harding JS;Zhang M;Sandor A;Christensen K;Nagy A;Sandor M;Fabry Z
通讯作者: Fabry Z
脑膜免疫调节学习和记忆:IL-4 的关键作用。
DOI: 10.1084/jem.20091419
发表时间: 2010-05-10
影响因子: 15.3
作者:
Derecki, Noel C.;Cardani, Amber N.;Yang, Chun Hui;Quinnies, Kayla M.;Crihfield, Anastasia;Lynch, Kevin R.;Kipnis, Jonathan
通讯作者: Kipnis, Jonathan
DOI: 10.1172/jci72189
发表时间: 2014-09-01
影响因子: 15.9
作者:
D'Alessio, Silvia;Correale, Carmen;Danese, Silvio
通讯作者: Danese, Silvio
DOI: 10.3171/jns.1986.65.5.0642
发表时间: 1986-11-01
影响因子: 4.1
作者:
GO, KG;HOUTHOFF, HJ;HAVINGA, P
通讯作者: HAVINGA, P
DOI: 10.1007/s10571-015-0273-8
发表时间: 2016-03
影响因子: 4
作者:
Bakker EN;Bacskai BJ;Arbel-Ornath M;Aldea R;Bedussi B;Morris AW;Weller RO;Carare RO
通讯作者: Carare RO