CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa
CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa
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DOI：
10.1126/science.290.5491.527
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发表时间：
2000-10-20
期刊：
影响因子：
56.9
通讯作者：
Gulbins, E
中科院分区：
文献类型：
--
作者：
Grassmé, H;Kirschnek, S;Gulbins, E
铜绿假单胞菌引起严重的感染，特别是肺部感染，这是危及生命的。在这里，我们表明，铜绿假单胞菌感染诱导肺上皮细胞凋亡的内源性CD 95/CD 95配体系统的激活。上皮细胞上的CD 95或CD 95配体的缺陷在体内以及体外阻止肺上皮细胞的凋亡。在铜绿假单胞菌感染后，CD 95或CD 95配体缺陷小鼠迅速发展为脓毒症，但在正常小鼠中没有，这证明了CD 95/CD 95配体介导的肺上皮细胞凋亡的重要性。
Pseudomonas aeruginosa causes severe infections, particularly of the lung, that are life threatening. Here, we show that P. aeruginosa infection induces apoptosis of lung epithelial cells by activation of the endogenous CD95/CD95 ligand system. Deficiency of CD95 or CD95 ligand on epithelial cells prevented apoptosis of lung epithelial cells in vivo as well as in vitro. The importance of CD95/CD95 ligand-mediated lung epithelial cell apoptosis was demonstrated by the rapid development of sepsis in CD95- or CD95 ligand-deficient mice, but not in normal mice, after P. aeruginosa infection.