Failure to remove autoreactive Vβ6+ T cells in Mls‐1a newborn mice attributed to the delayed development of B cells in the thymus
Failure to remove autoreactive Vβ6+ T cells in Mls‐1a newborn mice attributed to the delayed development of B cells in the thymus
复制标题
由于胸腺中 B 细胞发育迟缓，Mls-1a 新生小鼠未能清除自身反应性 Vβ6+ T 细胞
DOI：
10.1046/j.1365-2567.2000.00058.x
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发表时间：
2000
期刊：
影响因子：
6.4
通讯作者：
M. Hosono
中科院分区：
文献类型：
--
作者：
M. Touma;K. Mori;M. Hosono
胸腺自身反应性T细胞的克隆性删除是建立对自身抗原耐受性的主要机制之一，而携带Vβ6T细胞受体的自身反应性T细胞在成熟之前通常被删除。然而，这些T细胞在新生儿胸腺中短暂发育，并迁移到外围。为了了解这些潜在的自身毒性T细胞产生的机制，我们在体内研究了相关成分的生理或功能特性，如新生儿T细胞、抗原和抗原提呈细胞(APC)。我们证实了以前的发现，即这些元件本身在新生儿中已经完成了功能，我们调查了特定的APC与其自身产物MLS抗原在新生儿胸腺中缺失或未成熟的可能性。在研究新生儿胸腺的细胞和组织学变化时，我们发现Vβ6+T细胞的清除与胸腺B细胞的发育是平行的。B细胞参与清除新生儿胸腺中的自身反应性T细胞，经抗免疫球蛋白M抗体治疗后，可阻止Vβ6+T细胞的缺失。CD5在胸腺B细胞上有限而稳定地表达，而在脾细胞上不表达，这表明这些B细胞不是出生后从外周迁移过来的。结论：MLS-1a新生儿胸腺自身反应性T细胞缺失缺失是由于B细胞发育迟缓所致。
Clonal deletion of autoreactive T cells in the thymus is one of the major mechanisms for establishing tolerance to self‐antigens, and self‐reactive T cells bearing Vβ6 T‐cell receptors are usually deleted before their maturation in Mls‐1a mice. However, these T cells develop transiently in the neonatal thymus, and migrate to the periphery. In order to understand the mechanisms which permit these potentially auto‐toxic T cells to generate, we investigated in vivo the physiological or functional properties of the elements involved, such as neonatal T cells, antigens and antigen‐presenting cells (APC). Confirming the previous findings that each of these elements per se is already completed in function in neonates, we investigated the possibility of the absence or immaturity of particular APC with Mls antigens of their own products in the neonatal thymus. In the search for the cellular and histological changes occurring in the newborn thymus, we found that the elimination of Vβ6+ T cells progressed in parallel with the development of thymic B cells. Involvement of B cells in purging the autoreactive T cells from the newborn thymus was shown by prevention of the deletion of Vβ6+ T cells after the removal of B cells by the treatment of neonates with anti‐immunoglobulin M antibodies. The restricted and stable expression of CD5 on the thymic B cells, but not on the splenic cells, suggests that these B cells are not postnatal immigrants from the periphery. Finally, it is concluded that the deficiency in the deletion of self‐reactive T cells in the thymus of Mls‐1a neonates is due to the delayed development of B cells.
诱导新生儿对 Mls-1a 自身超抗原的耐受。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dannecker,G;Mecheri,S;Hoffmann,MK
通讯作者：
Hoffmann,MK
CD8 T 细胞诱导新生儿对 Mlsa 抗原的耐受。
DOI：
10.1126/science.1973003
发表时间：
1990
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Webb,SR;Sprent,J
通讯作者：
Sprent,J