Dopamine transporter levels in cocaine dependent subjects
Dopamine transporter levels in cocaine dependent subjects
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DOI：
10.1016/j.drugalcdep.2008.04.014
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发表时间：
2008-11-01
影响因子：
4.2
通讯作者：
Present, Julie
中科院分区：
文献类型：
--
作者：
Crits-Christoph, Paul;Newberg, Andrew;Present, Julie
可卡因的使用在美国是一个严重的问题，可卡因与大脑中的多巴胺转运蛋白（DAT）结合是公认的。本研究旨在确定通过Tc-99 mTRODAT SPECT（单光子发射计算机断层扫描）脑扫描测量的DAT水平是否在可卡因依赖受试者中发生改变，并探索此类改变的临床相关性。对21名可卡因依赖者和21名健康对照者进行SPECT脑扫描。与对照组相比，可卡因依赖受试者的前壳核DAT水平显著更高（p = 0.003，科恩d效应量= 0.98）。后壳核（p < 0.001，效应量= 1.32）。尾状核）= 0.003：效应量= 0.97）。与对照组相比，可卡因依赖受试者在这些区域的DAT水平分别高出10%、17%和8%。DAT水平与渴望、可卡因使用的严重程度或可卡因使用的持续时间无关。而尾状核和前壳核的DAT水平与距最后一次使用可卡因的天数呈显著负相关（p < 0.05）。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Cocaine use is a significant problem in the US and it is well established that cocaine binds to the dopamine transporter (DAT) in the brain. This study was designed to determine if the DAT levels measured by Tc-99m TRODAT SPECT (single photon emission computed tomography) brain scans are altered in cocaine dependent subjects and to explore clinical correlates Of Such alterations. SPECT brain scans were acquired on 21 cocaine dependent subjects and 21 healthy matched controls. There were significantly higher DAT levels in cocaine dependent subjects compared to controls for the anterior putamen (p = 0.003 Cohen's d effect size = 0.98). posterior putamen (p < 0.001 effect size = 1.32). and caudate) = 0.003: effect size = 0.97). DAT levels in these regions were 10%, 17%, and 8% higher in the cocaine dependent subjects compared to controls. DAT levels were unrelated to craving, severity of cocaine use, or duration of cocaine use. but DAT levels in the caudate and anterior putamen were significantly (p < 0.05) negatively correlated with days since last use of cocaine. (C) 2008 Elsevier Ireland Ltd. All rights reserved.