Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer - disparities in outcomes (ABC-DO) study
Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer - disparities in outcomes (ABC-DO) study
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DOI：
10.1002/ijc.31187
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发表时间：
2018-04-15
影响因子：
6.4
通讯作者：
McCormack, Valerie
中科院分区：
文献类型：
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作者：
McKenzie, Fiona;Zietsman, Annelle;McCormack, Valerie
撒哈拉以南非洲(SSA)的乳腺癌(BC)存活率很低，部分原因是确诊时处于晚期。作为对患有BC的SSA女性整个旅程研究的一个组成部分，我们的目标是确定共同的和特定于BC晚期的环境驱动因素。在多个国家的非洲乳腺癌-预后差异(ABC-DO)研究中新诊断的妇女完成了基线访谈，并从医疗记录中提取了她们的分期信息。采用有序Logistic回归方法估计晚期(I、II、III、IV期)的优势比(OR)和95%可信区间(CI)与女性个体水平、转诊和生物因素的关系。共有1795名来自尼日利亚、乌干达、赞比亚以及纳米比亚和南非的多种族人口的女性纳入研究，其中1091名(61%)为III/IV期。对BC知识了解较多的女性分期较低(OR0.77(95%CI：0.70，0.85)/分，满分为6分)。更高级的阶段与黑人有关(4.00(2.79，5.74))，参加过
Breast cancer (BC) survival rates in sub-Saharan Africa (SSA) are low in part due to advanced stage at diagnosis. As one component of a study of the entire journey of SSA women with BC, we aimed to identify shared and setting-specific drivers of advanced stage BC. Women newly diagnosed in the multicountry African Breast Cancer-Disparities in Outcomes (ABC-DO) study completed a baseline interview and their stage information was extracted from medical records. Ordinal logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for advanced stage (I, II, III, IV) in relation to individual woman-level, referral and biological factors. A total of 1795 women were included from Nigeria, Uganda, Zambia, and the multiracial populations of Namibia and South Africa, 1091 of whom (61%) were stage III/IV. Stage was lower in women with greater BC knowledge (OR 0.77 (95% CI: 0.70, 0.85) per point on a 6 point scale). More advanced stage was associated with being black (4.00 (2.79, 5.74)), having attended