An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses.
An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses.
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DOI：
10.1186/s12576-020-00751-4
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发表时间：
2020-05-04
期刊：
影响因子：
--
通讯作者：
Ogoh S
中科院分区：
文献类型：
--
作者：
Shibasaki M;Sato K;Hirasawa A;Sadamoto T;Crandall CG;Ogoh S
我们研究了在热应激过程中高碳酸血症引起的脑灌注升高对直立位挑战时的整体脑血管反应的影响。七名志愿者完成了一项渐进性下体负压（LBNP）挑战，以在热应激期间出现晕厥，有或没有呼吸高碳酸气体混合物。高碳酸混合气体的给药使潮气末CO2分压增加大于单独的预热应激，并增加颈内动脉（伊卡）和椎动脉（VA）的血流量（P < 0.05）。在LBNP期间，高碳酸气体混合物的伊卡和VA血流量相对于对照试验保持升高（P < 0.05）。然而，在LBNP结束时，由于晕厥前症状，伊卡和VA血流量在试验之间下降到相似的水平。这些结果表明，高碳酸血症诱导的脑血管舒张不足以维持脑灌注在年底的LBNP由于前晕厥或后血管床。
We investigated that the effects of hypercapnia-induced elevations in cerebral perfusion during a heat stress on global cerebrovascular responses to an orthostatic challenge. Seven volunteers completed a progressive lower-body negative pressure (LBNP) challenge to presyncope during heat stress, with or without breathing a hypercapnic gas mixture. Administration of the hypercapnic gas mixture increased the partial pressure of end-tidal CO2 greater than pre-heat stress alone, and increased both internal carotid artery (ICA) and vertebral artery (VA) blood flows (P < 0.05). During LBNP, both ICA and VA blood flows with the hypercapnic gas mixture remained elevated relative to the control trial (P < 0.05). However, at the end of LBNP due to pre-syncopal symptoms, both ICA and VA blood flows decreased to similar levels between trials. These findings suggest that hypercapnia-induced cerebral vasodilation is insufficient to maintain cerebral perfusion at the end of LBNP due to pre-syncope in either the anterior or posterior vascular beds.
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影响因子：
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作者：
Tatu, L;Moulin, T;Duvernoy, H
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